Publications
BIGS DrugS students and principal investigators have recently successfully published their research results. Congratulations!
2023
July 2023
Pepanian A, Binby FA, Roy S, Nubbemeyer B, Koley A, Rhodes CA; Ammer H, Pei D, Ghosh P, Imhof D. Bicyclic peptide library screening for the identification of Gαi protein modulators. J.Med. Chem.
Bockstiegel J, Wurnig SL, Engelhardt J, Enns J, Hansen FK, Weindl G.Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release. Biochem Pharmacol 215: 115693. doi: 10.1016/j.bcp.2023.115693
June 2023
Tahoun M, Engener M, Svolacchia L, Sander M, Müller CE: Molecular Taphonomy of Heme: Chemical Degradation of Hemin under Presumed Fossilization Conditions. Molecules 2023
May 2023
Javed H, Singh S, Urs Ramarajje S, Oldenburg J, Biswas A. Genetic landscape in coagulation factor XIII associated defects - Advances in coagulation and beypong. Blood Reviews
January 2023
Dauer K, Wagner KG. Micro-Scale Vacuum Compression Molding as a Predictive Sdreening Tool of Protein Integrity for Potential Hot-Melt extrusion Processes. Pharmaceutics
2022
December 2022
Dauer K, Werner C, Lindenblatt D, Wagner KG. Impact of process stress on protein stability in highly-loaded solid protein/PEG formualations from smal-scale melt extrusion. International Journal of pharmaceutics: X, 2022, 100154
November 2022
October 2022
Keuler T, Lemke C, Elsinghorst PW, Iriepa I, Chioua M, Martínez-Grau MA, Beadle CD, Vetman T, López-Muñoz F, Wille T, U. Bartz U, Deuther-Conrad W, J. Marco-Contelles J, Gütschow M. The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents; ACS Pharmacol. Transl. Sci. 2022, 5, 1097-1108.
Pepanian A, Sommerfeld P, Kasprzyk R, Kühl T, Binbay F, Hauser C, Löser R, Wodkte R, Bednarczyk M, Chrominski M, Kowalska J, Jemielity I, Imhof D, Pietsch M. A fluorescence anisotropy assy with guanine nucleotides provides access to functional analysis of Gαi1 proteins. Anal.Chem., 94 (41), 14418
September 2022
Müller CE, Claff T; Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain. Signal Transduction and targeted Therapy 2022, 7: 333; https://doi.org/10.1038/s41392-022-01162-0
Keuler T, König B, Bückreiß N, Kraft FB, König P, Steinebach C, Bendas G, Hansen FK. Development of first non-hydroxamate selective HDAC6 degraders ChemRxiv:DOI: 10.26434/chemrxiv--2022-3rhqf.
Hopp MT, Rathod D, Imhof D: Host and viral proteins involved in SARS-CoV-2 infection differentially bind heme. Protein Sci., e4451
August 2022
Abram M, Jakubiec M, Reeb K, Cheng MH, Gedschold R, Rapacz A, Mogilski S, Socała K, Nieoczym D, Szafarz M, Latacz G, Szulczyk B, Kalinowska-Tłuścik J, Gawel K, Esguerra CV, Wyska E, Müller CE, Bahar I, Fontana ACK, Wlaź P, Kamiński RM, Kamiński K. Discovery of (R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a novel orally bioavailable EAAT2 modulator with drug-like properties and potent antiseizure activity in vivo.
J. Med. Chem. 2022; https://doi.org/10.1021/acs.jmedchem.2c00534
Kohgo H, Mori T, Tanako Y, Yoshihaie K, Taniguchi K, Fujimoto K, Fritz L, Schneider T, Tsukazaki T: Crystal structure of the lipid flippase Mur J in a "squeezed" form distinct from its inward-and outward-facing forms Structure 2022, 4;30(8): 1085-1097
July 2022
Haerdtlein A, Boehmer A, Dafonde KK, Rottenkolber M, Jaehde U, Dreischulte T: Prioritisationof Adverse Drug Events Leading to Hospital Admission and Occuring during Hospitalisation: A RAND Survey J.Clin.Med. 2022 11 (15) 4254
Niemann B, Hauf-Brunsberg S, Puetz Laura, Freikert M, Yaeckstein MJ, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Mueller CE, Toenjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A: Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022)
June 2022
Mähler B, Janssen K, Tahoun M, Tomaschek F, Schellhorn R, Müller CE, Bierbaum G, Rust J; Adipocere formation in biofilms as a first step in soft tissue preservation. Sci. Rep. 2022, 12:10122. doi: 10.1038/s41598-022-14119-8.
Pillaiyar T, Flury P, Krüger N, Su H, Schäkel L, Barbosa da Silva E, Eppler O, Kronenberger T, Nie T, Luedtke S, Rocha C, Sylvester K, Petry MRI, McKerrow J, Poso A, . Pohlmann S, Gütschow M, O’Donoghue A, Xu Y, Müller CE, Laufer S. Small Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-activity Relationships, Antiviral Activity, and X-ray Structure Determination; J. Med. Chem. 2022, 65, 9376-9395.
May 2022
Miller DSJ, Voell SA, Sosič I, Proj M, Rossanese OW, Schnakenburg G, M. Gütschow M, Collins I, Steinebach C. Encoding BRAF Inhibitor Functions in Protein Degraders; RSC Med. Chem. 2022, 13, 731-736.
April 2022
Büschbell B, Manga P, Penner E, Schiedel AC: The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. Front. Mol. Biosci., 2022 , doi.org/10.3389/fmolb.2022.873777
Murgai A, Sosič I, Gobec M, Lemnitzer P, Proj M, Wittenburg S, Voget R, Gütschow M, Krönke J, Steinebach C: Expanding the PROTAC Toolbox: Targeted Degradation of the Deubiquitinase USP7 in Cancer; Chem. Commun. 2022, 58, 8858-8861.
Sosič I, Bricelj A, Steinebach C. E3 Ligase Ligand Chemistries: From Building Blocks to Protein Degraders; Chem. Soc. Rev. 2022, 51, 3487-3534.
Voss JH, Müller CE: Heteromeric G protein Þ-subunits - structure, petide-derived inhibitors, and mechanisms. Curr.Med.Chem
Vu LP, Zyulina M, Hingst A, Schnakenburg G, Gütschow M. Combinatorial Assembly, Traceless Generation and In Situ Evaluation of Inhibitors for Therapeutically Relevant Serine Proteases. Bioorg. Chem. 2022 121, 1105676.
March 2022
Modemann DJ, Mahardhika AB, Yamoune S, Kreyenschmidt AK, Maaß F, Kremers S,Breunig C, Sahlmann CO, Bucerius J, Stalke D, Wiltfang J, Bouter Y, Müller CE, Bouter C, Beller B. Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a readioactive tracer for imaging. Eur. J. Med. Chem. 2022, 232, 114138; https://doi.org/10.1016/j.ejmech.2022.114138.
Caniceiro AB, Büschbell B, Schiedel AC, Moreira IS: Class A and C GPCR dimers in neurodegenerative diseases. Current Neuropharmacology, 2022 doi:10.2174/1570159X20666220327221830
Neumann A, Attah IY, Al-Hroub H, Namasivayam V, Müller CE: Discovery of P2Y2 receptor antagonist scaffoldes through virtual high-throughput screening. J.Chem. Inf. Model. 2022, 62, 1538-49
Voss JH, Mahardhika AB, Inoue A, Müller CE. Agonist-Dependent Coupling of the Promiscuous Adenosine A2B Receptor to GÞ Protein Subunits. ACS Pharmacol. Transl. Sci.
Gockel LM, Nekipelov K, Ferro V, Bendas G, Schlesinger M. Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin. Cancer Immunol Immunother. doi: 10.1007/s00262-022-03186-5.
Febuary 2022
Losenkova K, Tkeda A, Ragauskas S, Cerrad-Gimenez M, Vähätupa M, Kaja S, Paul ML, Schmies CC, Rolshoven G, Müller CE, Sandholm J, Jalkanen S, Kalesnykas G, Yegutkin GG: CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity. Cell.Mol.Life Sci. 2022, 79,152
Claff T, Klapschinski TA, Udaya K, Subhramanyam T, Vaaßen VJ, Schlegel JG, Vielmuth C, Voß JH, Labahn J, Müller CE: Single stabilizing point mutation enables high-resolution co-crystal structures of the adenosine A2A receptor with preladenant conjugates. Angew. Chem. Int. Ed. 2022, e2022115545; doi.org/10.1002/anie.202115545
Gockel LM, Pfeifer V, Baltes F, Bachmaier RD, Wagner KG, Bendas G, Gütschow M, Sosič I, Steinebach C. Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models. Arch Pharm (Weinheim) 2022:e202100467. doi: 10.1002/ardp.202100467.
Keuler T, D. Ferber, Marleaux M, Geyer M, Gütschow M. Structure-Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas. ACS Omega 2022, 7, 8158-8162.
Ng YLD, Ramberger E, Bohl S, Dolnik A, Steinebach C, Conrad T, Müller S, Popp O, Kull M, Haji M, Gütschow M, Döhner H, Walther W, Keller U, Bullinger L, Mertins P, Krönke J. Proteomic Profiling Reveals CDK6 Upregulation as a Targetable Resistance Mechanism for Lenalidomide in Multiple Myeloma. Nat. Commun. 2022, 13, 1009
von Bredow L, Schäfer TM, Hogenkamp J, Tretbar M, Stopper D, Kraft FB, Schliehe-Diecks J, Schöler A, Borkhardt A, Bhatia S, Held J, Hansen FK. Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin.HDAC Inhibitor Hybrids as Multitarget Drugs. Pharmaceuticals, 15(3):333.
Tahoun M, Engeser M, Namasivayam V, Sander PM, Müller CE. Chemistry and Analysis of Organic Compounds in Dinosaurs Biology 2022, 11(5), 670
January 2022
Scortichini M, Idris RM, Moschütz S, Keim A, Slamaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA;
Structure-activity relationship of 3-methylcytidine-5’-α,β-methylenediphosphates as CD73 inhibitors. J. Med. Chem. 2022, 65, 2409-2433; https://doi.org.10.1021/acsjmedchem.1c01852.
Schäker-Hübner L, Haschemi R, Büch T, Kraft FB, Brumme B, Schöler A, Jenke R, Meiler J, Aigner A, Bendas G, Hansen FK. Balancing Histone Deacetylase (HDAC) Inhibitors and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors. ChemMedChem.
Schulte B, König M, Escher BI, Wittenburg S, Proj M, Wolf V, Lemke C, Schnakenburg G, Sosič I, Streeck H, Müller CE, Gütschow M, Steinebach C. Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent anti-SARS-CoV-2 Activity ChemMedChem 2022, 17, e202100732
Nubbemeyer B, Ajay Abisheck PG, Kühl T, Pepanian A, Beck MS, Maghraby R, Boushehri MS, Mühlhaupt M, Pfeil EM, Annala SK, Ammer H, Imhof D, Pei D. Targeting Gαi/s Proteins with peptidyl Nucleotide Exchange Modulators ACS Chem. Bio.2022
2021
December 2021
Mc Laughlin AM, Schmulenson E, Teplytska O, Zimmermann S, Opitz P, Groenland SL, Huitema ADR, Steeghs N, Müller L, Fuxius S, Illerhaus G, Joerger M, Mayer F, Fuhr U, Holdenrieder S, Hempel G, Scherf-Clavel O, Jaehde U, Kloft C, for the ON-TARGET Study Consortium. Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol.
Cancers 2021; 13(24):6281.
Vu LP, Gütschow M.Diketomorpholines: Synthetic Accessibility and Utilization.
ACS Omega 2022, 7, 48-54
November 2021
Voss JH, Nagel J, Rafehi M, Guixa-Gonzalez DM, Patt J, Kehraus S, Inoue A, König GM, Kostenis E, Xavier D, Namasivayam V, Müller CE: Unraveling binding mechanism and kinetics of macrocyclic GÞq protein inhibitors. Pharmacol. res.2021, 153, 105880
Klöppel S, Richarz R, Wirtz DA, Vasenda N, König GM,Crüsemann M. A specialized dehydrogenase provides l-phenyllactate for FR900359 biosynthesis. ChemBioChem 10.1002/cbic.202100569.
October 2021
Schäkel L, Mirza S, Pietsch M, Lee SY, Keuler T, Sylvester K, Pelletier J, Sévigny J, Pillaiyar T, Gütschow M, Müller CE. 2-Substituted Thienotetrahydropyridine Derivatives – Allosteric Ectonucleotidase Inhibitors; Arch. Pharm. 2021, 354, e2100300.
Bricelj A, Ng YLD, Ferber D, Kuchta R, Müller S, Monschke M, Wagner KG, Krönke J, Sosič I, Gütschow M, Steinebach C. Influence of Linker Attachment Points on Stability and Neosubstrate Degradation of Cereblon Ligands; ACS Med. Chem. Lett. 2021, 12, 1733-1738.
September 2021
Voss JH, Nagel J, Rafehi M, Guixà-González R, Malfacini D, Patt J, Kehraus S, Inoue A, König GM, Kostenis E, Deupi X, Namasivayan V, Müller CE. Unraveling binding mechanism and kinetics of macrocyclic GÞq protein inhibitors Pharmalogical Research
Lemke C, Benýšek J, Brajtenbach D, Breuer C, Jílková A, Horn M, Buša M, Ulrychová L, Illies A, Kubatzky KF, Bartz U, Mareš M, Gütschow M. An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity; J. Med. Chem
August 2021
Büschbell B, Manga P, Penner E, Schiedel AC: Evidence for Protein-Protein Interaction between Dopamine receptors and the G Protein-Coupled Receptor 143 Int. J. Mol. Sci. 22(15), 8328
Dolšak A, Šribar D, Scheffler A, Grabowski M, Švajger U, Gobec S, Holze J, Weindl G, Wolber G, Sova M: Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure–activity relationships. Eur J Med Chem 225:113809.
July 2021
Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Zamora Gonzalez N, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother P, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A. Dysfunction of the Key Ferroptosis-surveilling Systems Hypersensitizes Mice to Massive Tubular Necrosis During Acute Kidney Injury; Nat. Commun.
Hanke W, Patt J, Alenfelder J, Voss JH, Zdouc MM, Kehraus S, Kim JB, Grujicic, Namasivagam V, Reher R, Müller CE, Kostenis E, Crüseman M, König GM. Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives. J.Nat. Prod. 2021
Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayash Yi. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents;
J. Med. Chem
Bricelj A, Steinebach C, Kuchta R, Gütschow M, Sosič I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points;
Front. Chem.
June 2021
Lopez Marmol A, Denninger A, Touzet A, Dauer K, Becker T, Pöstges F, Pellequer Y, Lamprecht A, Wagner KG. The Relevance of Supersaturation ans Solubilization in the Gastrointestinal Tract for oral Bioavailability: An In Vitro vs. In Vivo Approach. International Journal of Pharmaceutics.
Thanigaimalai P, Masoud S, Andhika BM, Wendt LL, Müller CE: Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetriyal diindoylmethanes with a quarternary carbon center. Beilstein J. Org. Chem. 2021, 17, 1464-1475.
Lee SY, Namasivayam V, Boshta NM, Perotti A, Mirza S, Bua S, Supuram CT, Müller CE: Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) with ancillary carbonic anhydrase inhibition for cancer 8immune)therapy. RCS Med. Chem.2021, 12, 1187-1206
Wirtz DA, Ludwig KC, Arts M, Marx CE, Krannich S, Barac P, Kehraus S, Josten M, Henrichfreise B, Müller A, König GM, Peoples AJ, Nitti A, Spering AL, Losee LL, Lewis K, Crüsemann M, Schneider T. Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin. Angew Chem Ing Ed Engl; 60(24)13579-13586
Sosič I, Gobec M, Steinebach C, Schlesinger M, Bendas G, M. Gütschow M. Another Structural Correction for 1-Oxo-1H-phenalene-2,3-dicarbonitriles: Synthesis of a Potent BCL-2 Inhibiting 7-Phenoxy Derivative; Arch. Pharm.
May 2021
Wu Z, Deshpande T, Henning L, Bedner P, Seifert G, Steinhäuser C. Cell death of hippocampal CA1 astrocytes during early epileptogenesis. Epilepsia. 62 (7):1569-1583
Henning L, Steinhäuser C, Bedner P. Initiation of Experimental Temporal Lobe Epilepsy by Early Astrocyte Uncoupling Is Independent of TGFβR1/ALK5 Signaling. Front Neurol 12:660591.
April 2021
Hopp MT, Domingo-Fernández D, Gadiya Y, Detzel MS, Graf R, Schmalohr BF, Kodamullil AT, Imhof D, Hofmann-Apitius M. Linking COVID-19 and heme-driven pathophysiologies: A combined computational-experimental approach. Biomolecules, 2021, 11, 644
Hermes C, König GM, Crüseman M. The chromodepsins - chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family. Nat. Prod. Rep. 2021 https://doi.org/10.1039/D1NP00005E
Keuler T, Gatterdam K, Akbal A, Lovotti M, Marleaux M, Geyer M, Latz L, Gütschow M. Development of Fluorescent and Biotin Probes Targeting NLRP3. Front. Chem. 2021, 9, 642273.
López Mármol Á, Denninger A, Touzet A, Dauer K, Becker T, Pöstges F, Pellequer Y, Lamprecht A, Wagner KG. The relevance of supersaturation and solubilization in the gastrointestinal tract for oral bioavailability: an in vitro vs. In vivo approach. Int j pharm. https://doi.org/10.1016/j.ijpharm.2021.120648
March 2021
and Granule Secretion. Methods Mol Biol 2021; 2294:181–95. doi: 10.1007/978-1-0716-1350-4_13.
Wirtz DA, Ludwig KC, Arts M, Marx CE, Krannich S, P. Barac P, Kehraus Josten SM, Henrichfreise B, Müller A, König GM, Peoples J, Nitti A, Spoering AL, Ling LL, Lewis K, Crüsemann M, Schneider T. Biosynthesis and mechanism of action of the cell wall targeting antibiotic hypeptin. Angew. Chem. Int. Ed. 2021, 60, doi.org/10.1002/ange.202102224
Haschemi R, Gockel LM, Bendas G, Schlesinger M. A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells. Int J Mol Sci 2021; 22(7). doi: 10.3390/ijms22073323.
Dauer K, Kamm, W, Wagner KG, Pfeifer-Marek S. High-Throughput Screening for Colloidal Stability of Peptide Formulations Using Dynamic and Static Light Scattering. Mol. Pharmaceutics
Breidenbach J, Lemke C, Pillaiyar T, Schäkel L, Al Hamwi G, Diett M, Gedschold R, Lopez V, Mirza S, Namasivayan V, Schiedel AC, Sylvester K, Thimm D, Vielmuth C, Phuong Vu L, Zyulina M, Geiger N, Bodem J, Gütschow M, Müller CE: Targeting the Main Protease of SARS-CoV-2: From th Establishment of Hight Throughput Screening to the Design of Tailored Inhibitors. Angew. Chem. Ind. Ed.
Schmalohr BF, Mustafa A-H.M, Krämer OH, Imhof D. Structural insights into the interaction of heme with protein tyrosine kinase JAK2. ChemBioChem, 22(5), 861-864
February 2021
Tahoun M, Gee CT, McCloy VE, Sander M, Müller CE. Chemistry of Porpyrins in fossil Plants and animals. RSC Adv. 2021, 11, 7552-7536
Detzel MS, Schmalohr BF, Steinbock F, Hopp MT, Ramoji A, Paul George AA, Neugebauer U, Imhof D. Revisiting the interaction of heme with hemopexin. Biol. Chem.
Schlegel JG, Tahoun M, Seidinger A, Voss JH, Kuschak M, Kehraus S, Schneider M, Matthey M, Fleischmann BK, König GM, Wenzel D, Müller CE. Macrocyclic Gq protein inhibitors FR900359 and/or YM-254890−fit for translation? ACS Pharmacol. Transl. Sci. 2021, 4, 888-897.
Patt J, Alenfelder J, Pfeil E, Voss JH, Merten N, Eryilmaz F, Heycke N, Ricki U, Inoue A, Kehraus S, Deupi X, Mueller CE, Koenig GM, Cruesemann M, Kostenis E. An experimental strategy to probe Gq contribution to signal tansduction in living cells. J. Biol. Chem. 2021, 296, 100472
Gockel LM, Heyes M, Li H, Al Nahain A, Gorzelanny C, Schlesinger M, Holdenrieder S, Li J-P, Ferro V, Bendas G. Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics. ACS Appl Mater Interfaces 2021; 13(6):7080–93. doi: 10.3390/molecules23112753
Nubbemeyer B, Pepanian A, Paul George A A., Imhof D. Strategies Towards Targeting Gαi/s Proteins: Scanning of Protein-Protein Interaction Sites to Overcome Inaccessibility. ChemMedChem.
January 2021
Jílková A, Horn M, Fanfrlík J, Küppers J, Pachl P, Řezáčová P, Lepšík M, Fajtová P, Rubešová P, Chanová M, Caffrey CR, Gütschow M, Mareš. Azanitrile Inhibitors of the SmCB1 Protease Target are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivit. ACS Infect. Dis. 2021, 7, 189-201.
Hermes C, Richarz R, Wirtz D, Patt J, Hanke W, Kehraus S, Voss JH, Küppers T, Ohbayashi T, Namasivayam V, Alenfelder J, Inoue A, Mergaert P, Gütschow M, Müller CE Kostenis E, König G, Crüsemann M.Thioesterase-mediated Side Chain Transesterification Generates Potent Gq Signaling Inhibitor FR900359. Nat. Commun. 2021, 12, 144
Heim C, Maiwald S, Steinebach C, Collins MK, Strope J, Chau CH, Figg WD, Gütschow M, Hartmann MD.On the Correlation of Cereblon Binding, Fluorination and Antiangiogenic Properties of Immunomodulatory Drugs. Biochem. Biophys. Res. Commun. 2021, 534, 67-72.
Danish A, Gedschold R, Hinz S, Schiedel AC, Thimm D, Bedner P, Steinhäuser C, Müller CE. A Cellular Assay for the Identification and Characterization of Connexin Gap Junction Modulators. In. J. Mol. Sci. 22(3) 1417
Lopez V, Schäkel L, Schuh MJM, Schmidt MS, Mirza S, Renn C, Pelletier J, Lee SY, Sévigny J, Alban S, Bendas G, Müller CE. Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidase NPP1 and CD39. Mar Drugs 22;19 (2):51
Dauer K, Pfeiffer-Marek S, Kamm W, Wagner K. Microwell Plate-Based dynamic Light Scattering as a High-Throughput Characterization Tool in Biopharmaceutical Development. Pharmaceutics 2021 13(2), 172
Hopp MT, Imhof D. Linking Labile Heme with Thrombosis. J. Clin. Med., 10(3), 427
Schmitz T, Paul George AA., Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D. NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure–Activity Relationships. Int. J. Mol. Sci., 22, 880
Hopp MT, Alhanafi N, Paul George AA., Hamedani N S, Biswas, A, Oldenburg J, Pötzsch B, Imhof D. Molecular insights and functional consequences of the interaction of heme with activated protein C. Antioxid. Redox Signal., 34(1), 32-48
2020
December 2020
Müller J, Timmermann A, Henning L, Müller H, Steinhäuser C , Bedner P. Astrocytic GABA accumulation in experimental temporal lobe epilepsy. Frontiers Neurol 11:614923.
Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E. Heterotrimeric G protein subunit Gaq is a master switch for Gbg-mediated calcium mobilization by Gi-coupled GPCRs. Cell 2020, https://doi.org/10.1016/j.molcel.2020.10.027
November 2020
Mäher B, Jansen K, Menneken M, Tahoun M, Lagos M, Bierbaum G, Müller CE, Rust J. Calcite precipitation forms crystal cluster and muscle mineralization during the decomposition of Cambarellus diminutes (Descapoda: Cambaridae) in freshwater. Palaeontologia Electronica 2020, 23, a56
Krome AK, Becker T, Kehraus S, Schiefer A, Steinebach C, Aden T,Frohberge SJ, López Mármol Á, Kapote D, Jansen R, Chaverra-Muñoz l, Hübner MP, Pfarr K, Hesterkamp T, Stadler M, Gütschow M, König GM, Hoerauf A, Wagner KG. Solubility and stability enhanced oral formulations for the anti-infective Corallopyronin A. Pharmaceutics 2020, 12, 1005.
Wantoch von Rekowski K, König P, Henze S, Schlesinger M, Zawierucha P, Januchowski R, Bendas G. Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies. Int J Mol Sci 2020; 21(23). doi: 10.3390/ijms21239240.
October 2020
Vucur C, Wirtz DA, Weinhold L, Zipfel M, Schmid M, Schmidt-Wolf IG, Jaehde U.
Drug-related problems in head and neck cancer patients identified by repeated medication reviews on consecutive therapy cycles. J Oncol Pharm Pract 2020
Korff M, Imberg L, Will JM, Bückreiß N, Kalinina SA, Wenzel BM, Kastner GA, Daniliuc CG, Barth M, Ovsepyan RA, Butov KR, Humpf H-U, Lehr M, Panteleev MA, Poso A, Karst U, Steinmetzer T, Bendas G, Kalinin DV. Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action. J Med Chem 2020; 63(21):13159–86. doi: 10.1021/acs.jmedchem.0c01635.
Küppers J, Benkel T, Annala S, Kimura K, Reinelt L, Fleischmann BK, Kostenis E, Gütschow M. Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation As Gαq-Protein Ligands. Chem. Eur. J. 2020, 26, 12615-12623.
Barakat AK, Scholl C, Steffens M, Brandenburg K, Ising M, Lucae S, Holsboer F, Laje G, Kalayda GV, Jaehde U, Stingl JC. Citalopram-induced Pathways Regulation and Tentative Treatment-Outcome-Predicting Biomarkers in Lymphoblastoid Cell Lines From Depression Patients. Transl Psychiatry 2020; 10: 210
September 2020
Kuschak M, Schlegel JG, Schneider M, Kehraus S, Voss JH, Seidinger A, Matthey M, Wenzel D, Fleischmann BK, König GM, Müller CE. Sensitive LC-MS/MS method for the quantification of macrocyclic Gαq protein inhibitors in biological samples. Front. Chem. 2020, 8, 833.
Breidenbach J, U. Bartz, Gütschow M.Coumarin as a Structural Component of Substrates and Probes for Serine and Cysteine Proteases. Biochim. Biophys. Acta Proteins Proteom. 2020, 1868, 140445.
Peach ML, Beedie SL, Chau CH, Collins MK, Markolovic S, Luo W, Tweedie D,
Steinebach C, Greig NH, Gütschow M, Vargesson N, Nicklaus MC, Figg WD. Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs. Molecules 2020, 25, 5683.
Schäkel L, Schmies CC, Idris RM, Luo X, Lee SY, Lopez V, Mirza S, Vu TH, Pelletier J, Sévigny J, Namasivayan N, Müller CE. Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors. Front. Pharmacol. 11, 1-23
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schäkel L, Al-Hroub H, Wang Y, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Müller CE. Fluorescent probes for Ecto-5'-nucleotidase (CD73). ACS Med. Chem Lett.
Lemke C, Cianni l, Fledmann C, Gilberg E, Yin L, dos Reis Rocho F, de Vita D, Bartz U, Bajorath J, Montanari CA, Gütschow M.N-Sulfony dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical charaterization. Bioorganic & Medicinal Chemistry letter, Vol. 30, Issue 18
Bäuml C, Paul George AA, Schmitz T, Sommerfeld P, Pietsch M, Podsiadlowski L, Steinmetzer T, Biswas A, Imhof D. Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity. Eur. J. Med. Chem., 201, 112474
Schmitz T, Bäuml CA, Imhof D. Inhibitors of blood coagulation factor XIII. Anal. Biochem., 605, 113708
August 2020
Zaluski M, Schabikowski J, Jasko P, Bryla A, Olejarz-Maciej A, Kaleta M, Gluch-Lutwin M, Brockmann A, Hinz S, Zygmunt M, Kuder K, Latacz G, Vielmuth C, Müller CE, Kiec-Kononowicz K. 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation. Bioorg. Chem. 2020, 101, 104033
Baqi Y, Rashed M, Schäkel L, Malik EM, Pelletier J, Sévigny J, Fiene A, Müller CE. Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitor With Selectivity for NTPDase2 and NDPDase3. Front. Pharmacol. 11, 1-1
Pillaiyar T, Wendt LL, Manickam M, Easwaran M. The recent outbreaks of human coronavirus: A medicinal chemistry perspective. Medicinal research reviews
Hopp MT, Alhanafi, N, Paul George, AA, Hamedani NS, Biswas A, Oldenburg J, Pötzsch B, Imhof D. Molecular insights and functional consequences of the interaction of heme with activated protein C. Antioxid. Redox Signal.
Schmulenson E, Krolop L, Simons S, Ringsdorf S, Ko YD, Jaehde U. Evaluation of patient-reported severity of hand-foot syndrome under capecitabine using a markov modeling approach. Cancer Chemotherapy and Pharmacology
Lopez V, Lee SY, Stephan H, Müller CE. Recombinat expression of ectonucleotide pyrophosphatase/phosphodiesterase 4 (NPP4) and development of a luminescence-based assay to identify ihibitors. Analytical biochemistry, Vol 603, 113774
July 2020
Baltes F, Caspers J, Henze S, Schlesinger M, Bendas G. Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β1-integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding. Int J Mol Sci. (2020)
Silbermann K, Li J, Namasivayam V, Baltes F, Bendas G, Stefan SM, Wiese M. Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-spectrum ABCB1, ABCC1, and ABCG2 Antagonists. J. Med.Chem. (2020)
Kannabivan SA, Gosejacob D, Niemann B, Nikolaev VO, Pfeifer A. Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of ß1 and ß2-adrenoceptor signaling. Molecular metabolism, Vol 37, 1-11
Rivière S, Vielmuth C, Ennenbach CA, Abdelrahman A, Lemke C, Gütschow M, Müller CE, Menche D. Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids. ChemMedChem, Vol 15, Issue 14, 1348-1368
Ipsit S, Vazquez-Juraez E, Henning L, Gómes-Galán N, Lindskog M. Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression. Cells 2020, Vol 9, Issue 7, 1705
Syllwasschy BF, Beck MS, Družeta I, Hopp MT, Ramoji A, Neugebauer U, Nozinovic S, Menche D, Willbold D, Ohlenschläger O, Kühl T, Imhof D. (2020).High-affinity binding and catalytic activity of His/Tyr-based sequences: Extending heme-regulatory motifs beyond CP. Biochim. Biophys. Acta - General subjects, 1864 (7), 129603
Ortland I, Mendel Ott M, Kowar M, Sippel C, Jaehde U, Jacobs AH, Ko YD.
Comparing the performance of the CARG and the CRASH score for predicting toxicity in older patients in cancer. J Geriatr Oncol 2020; 11:997-1005.
Schmitz T, Pengelley, S., Belau, E, Suckau D, Imhof D. LC-Trapped Ion Mobility Spectrometry-TOF MS Differentiation of 2-and 3-Disulfide-Bonded Isomers of the μ-Conotoxin PIIIA. Anal. Chem., 92(16), 10920–10924
June 2020
Schoeder CT, Mahardhika AB, Drabczynska A, Kiec-Kononowicz K, Müller CE. Discovery of tricyclic xanthines as agonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18. ACS Med. Chem Lett 2020, 11, 2024-2031
Kuwahara-Ota S, Shimura Y, Steinebach C, Isa R, Yamaguchi J, Nishiyama D, Fujibayashi Y, Takimoto-Shimomura T, Mizuno Y, Matsumura-Kimoto Y, Tsukamoto T, Chinen Y, Kobayashi Y, Horiike S, Taniwaki M, Gütschow M, Kuroda J;
Lenalidomide and Pomalidomide Potently Interfere with Induction of Myeloid-derived Suppressor Cells in Multiple Myeloma. Br. J. Haematol. 2020, 191, 784-795.
Hopp MT, Schmalohr BF, Kühl T, Detzel MS, Wissbrock A, Imhof D. Heme Determination and Quantification Methods and Their Suitability for Practical Applications and Every-Day-Use. Anal. Chem. 92 (14), 9429-40
Li X, Höhl R, Sörgel F, Fuhr U. The parent drugs chloroquine and hydroxchloroquine do not inhibit human CYP3A activity in vitro. European Journal of Clinical Pharmacology
May 2020
Baltes F, Pfeifer V, Silbermann K, Caspers J, Wantoch von Rekowski K, Schlesinger M, Bendas G. Beta1-Integrin binding to collagen type 1 transmits breast cancer cells into chemoresistance by activating ABC efflux transporters. Biochim Biophys Acta Mol Cell Res. (2020)
Lübow C, Bockstiegel J, Weindl G.Lysosomotropic drugs enhance pro-inflammatory responses to IL-1ß in macrophages by inhibiting internalization of IL-1 receptor. Biochem Pharmacol 175, 113864
Möltgen S, Piumatti E, Massafra GM, Metzger S, Jaehde U, Kalayda GV. Cisplatin Protein Binding Partners and Their Relevance for Platinum Drug Sensitivity. Cells 2020; 9: E1322.
Li X, Junge L, Taubert M, von Georg A, Dahlinger D, Starke C, Frechen S, Stelzer C, Kinzig M, Sörgel F, Jaehde U, Töx U, Goeser T, Fuhr U.A Novel Study Design Using Continuous Intravenous and Intraduodenal Infusions of Midazolam and Voriconazole for Mechanistic Quantitative Assessment of Hepatic and Intestinal CYP3A Inhibition. J Clin Pharmacol 2020 [Epub ahead of print]
Steinebach C, Voell SA, Vu LP, Bricelj A, Sosic I, Schnakenburg G, Gütschow M. A Facile Synthesis of Ligands for the von Hippel-Landau E Ligase. Synthesis 202052, A-G
April 2020
Deshpande T, Tingsong L, Henning L, Wu Z, Müller J, Seifert G, Steinhäuser C, Bedner P. Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy. Glia 68:2136-2147.
Kuschak M, Namasivagam V, Fafehi M, Voss JH, Gars J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischman BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE. Cell-permeable high-affinity tracer for Gq proteins provide structural insights reveal distinct binding kinetis and identify small molecule inhibitors. BJP, 177,8, 1898-1916
Nakamura T, Harada K, Kamiya T, Takizawa M, Küppers J, Nakajima K,Gütschow M, Kitaguchi T, Ohta K, Kato T, Tsuboi T.Glutamine-induced Signaling Pathways via Amino Acid Receptors in Enteroendocrine L Cell Lines. J. Mol. Endocrinol. 2020, 64, 133-143.
March 2020
Attah IY, Neumann A, Al-Hroub H, Rafehi M, Baqi Y, Namasivayam V, Müller CE.
Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4
receptors elucidated by mutagenesis, pharmacological and computational studies. Biochim. Biophys. Acta Gen. Subj. 2020, 1864, 129501.
Köse M, Pillaiyar T, Namasivayan V, De Fillippo E, Sylvester K, Ulven T, von Kügelgen I, Müller CE. An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem, Vol 63, Issue 5, 2391-2410
Cianni l, Lemke C, Gilberg E, Feldmann C, Rosini F, Dos Reis Rocho Ribeiro JFR, tezuka DY, Lopez CD, de Albuquerque S, Bajorath J, Laufer S, Leitão A, Gütschow M, Montanari CA. Mapping the S1 and S1' Subsites of Cysteine Proteases with New Dipeptidyl Nitrile Inhibitors as Trypanoicidal Agents. PLoS Negl. Trop.
Dephande T, Li T, Henning L, Zhou W, Müller J, Seifert G, Steinhäuser C, Bedner P. Constitutive deletion of astrocytic vonnexins aggravates kainate-induced epilepsy. Glia. 2020, 1-12
Humayun F, Domingo-Fernandez D, Paul George AA, Hopp MT, Syllwasschy BF, Detzel MS, Hoyt TC, Hofmann-Apitius M, Imhof D. (2020). A computational approach for mapping heme biology in the context of hemolytic disorders. Front.Bioeng.Biotechnol.,8,74
Paul George AA, Lacerda M, Syllwasschy BF, Hopp MT, Wißbrock A, Imhof D. HeMoQuest: A webserver for qualitative prediction of transient heme binding to protein motifs. BMC Bioinformatics, 21, 124
Steinebach C, Ng YLD, Sosič I, Lee C, Chen S, Lindner S, Vu LP, Bricelj A, Haschemi R, Monschke M, Steinwarz E, Wagner KG, Bendas G, Luo J, Gütschow M, Krönke J. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chem.Sci. 2020, 11, 3474-3486
Neumann A, Müller CE, Namasivayam V. P2Y1-like nucleotide receptors - Structures, molecular modeling, mutagenesis, and oligomerization. WIREs comput. Mol. Scie 2020, 10 e1416; doi: 10.1002/wcms.1461
Neumann A, Engel V, Mahardhika AB, Schoeder CT, Namasivayam V, Kiec-Kononowicz K, Müller CE. Computational investigations on the binding mode of ligands for the cannabinoid-activated g protein-coupled receptor GPR18. Biomolecules 2020, 10, 686; doi:10.3390/bioml10050686
February 2020
De Filippo E, Hinz S, Pellizzari V, Deganutti G, El-Tayeb A, Navarro G, Franco R, Moro S, Schiedel AC, Müller CE. A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine. Biochem Pharmacol. 172, 113718; https://doi.org/10.1016/j.bcp.2019.113718.
Melo R, Lemos A, Preto AJ, Bueschbell B, Matos-Filippe P, Barreto C, Almeida JG, Silva RDM, Correia JDG, Moreira IS. An Overview of Antiviral Agents for Treating HIV Infection in Paediatric Population. Medicinal Chemistry, Vol 27, issue 5, 760-794
Bhattari S, Pippel J, Scaletti E, Idris R, Freudenlieb M, Rolshoven G, Renn C, Lee SY, Abdelrahman A, Zimmermann H, El-Tayeb A, Müller CE, Sträter N. 2-Substituted α, ß-methylene-ADP Derivatives: Potent competitives Ecto-5'-nucleotidase (CD73) inhibitors with Variable Binding Modes. J. Med. Chem. 2020, 63, 2941-2957
Schwarz S, Gockel L, Naggi M, Gobec M, Bendas G, Schlesinger M. Glycosaminogylcans as Tools to Decipher the Platelet Zumor Cell Interaction: a Focus on P-Selectin. Molecules, Vol 25, Issue 5, 1039
Dilruba S, Grondana A, Schiedel AC, Ueno NT, Bartholomeusz C, Cinatl J Jr, McLaughlin KM, Wass MN, Michaelis M, Kalayda GV. Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin. Cells 2020; 9: E515.
January 2020
Pillaiyar T, Funke M, Al-Hroub H, Weyler S, Ivanova S, Abdelrahman A, Müller CE.
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur. J. Med. Chem. 2020, 186, 111789.
Abdelrahman A, Yerande SG, Namasivayam V, Klapschinski TA, Alnouri MW, El-Tayeb A, Müller CE. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists. Eur J. Med. Chem. 2020, 186, 111879.
Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE; Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors. Br. J. Pharmacol. 2020, 177, 1898-1916; https://doi.org/10.1111/bph.14960.
Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Katharina Sylvester, Trond Ulven, von Kügelgen I, Müller CE; An agonist radioligand for the proinflammatory lipid-activated G protein-coupled receptor GPR84 providing structural insights.
J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.9b01339.
2019
December 2019
Li X, Frechem S, Moi D, Lehr T, Taubert M, Hsin CH, Mikus G, Neuvoven PJ, Olkkola KT, Saari TI, Fuhr U. A Physiological based Pharmacokinetik Model of Voriconazole Integrating Time-Dependent Interaction of CYP3A4, Genetic Polymorphisms of CYP2C19 and prediction of Drug-Drug Interaction. Clinical Pharmacokinetics 59, 781-808
Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martínez-Grau MA, Beadle CD, Vetman T, Dato FM, Bartz U, Elsinghorst PW, Pietsch M, Müller CE, Iriepa I, Wille T, Marco-Contelles J, Gütschow M.Chromenones as Multi-Neurotargeting Inhibitors of Human Enzymes. ACS Omega 2019, 4 22161-22168
Klepac K, Yang J, Hildebrand S, Pfeifer A. RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation. Mol Metab. 2019 Dec;30:173-183. doi: 10.1016/j.molmet.2019.09.015.
November 2019
Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Raymond C. Stevens RC. Elucidating the active δ-opioid receptor crystal strucure with peptide and small-molecule agonists. Sci. Adv. 2019, 5, eaax9115.
Singh S, Nazabal A, Kaniyappan S, Pellequer JL, Wolberg AS, Imhof D, Oldenburg J, Biswas A. The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex. Biomolecules, 9(12), 765
Wißbrock A, Goradia NB, Kumar A, Paul George AA, Küh T, Bellstedt P, Ramachandran, R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Structural insights into heme binding to IL-36α proinflammatory cytokine. Sci. Rep.,9,16893
Kumar A, Bellstedt P, Wiedemann C, Wißbrock A, Imhof D, Ramachandran R, Ohlenschläger O. NMR experiments on the transient interaction of the intrinsically disordered N-terminal peptide of cystathionine-β-synthase with heme. J. Magn. Reson., 308, 106561
October 2019
Nassir M, Mirza S, Arad U, Lee SY, Rafehi M, Attha IY, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B. Adenine-(methoxy)-ethoxy-Pα,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes. Org. Biomol. Chem. 2019, 17, 9913-9923.
Wantoch von Rekowski K, König P, Henze S, Schlesinger M, Zawierucha P, Januchowski R, Bendas G. The Impact of Integrin-Mediated Matrix Adhesion on Cisplatin Resistance of W1 Ovarian Cancer Cells. Biomolecules 2019.
September 2019
Undap NIJ, Papu A, Chillo D, Gruber F, Kaligis F, Lepar M, Hertzer C, Böhringer N, König GM, Schäberle TF, Wägele H. First survey of heterobranch sea slugs (Mollusca, Gastropoda) from the island Sangihe, North Sulawesi, Indonesia. Diversity, 2019, 11, 170.
Tietze D, Kaufmann D, Tietze AA, Voll A, Reher R, König GM, Hausch F. Structural and dynamical basis of G protein inhibition by YM-254890 and FR900359: an inhibitor in action. J. Chem. Inf. Model, 2019, 59, 4363-4373
Küppers J, Hympánová M, Keuler T, Schneider AJ, Schnakenburg G, Gütschow M.
Transformation of the Carboxyl Group of an Amino Acid to Variously Substituted Imidazoles through a Davidson-type Heterocyclization. Synthesis 2019, 51, 1961-1068.
Martinez-Lagunas K, Yamaguchi Y, Becker C, Geiger C, DeRuiter MC; Miura M, Fleischmann BK, Hesse M. In vivo detection of programmed cell death during mouse heart development. Cell & Death Differentiation; 27, 1398-1414
Bäuml C A, Imhof D. Tridegin as FXIIIa inhibitor. Zedira GmbH, Blog Entry: https://zedira.com/Blog/Tridegin-as-FXIIIa-inhibitor_118
August 2019
Küppers J, Benkel T, Annala S, Schnakenburg G, Kostenis E, Gütschow M. BIM-46174 Fragments as Potential Ligands of G Proteins. Med. Chem. Commun. 2019, 10, 1838-1843.
Singh S, Dodt J, Volkers P, Hethershaw E, Philippou H, Ivaskevicius V, Imhof D, Oldenburg J, Biswas A. Structure functional insights into calcium binding during the activation of coagulation factor XIII A. Sci. Rep., 9, 11324
July 2019
Bhattarai S, Pippel J, Meyer A, Freundlieb M, Schmies C, Abdelrahman A, Fiene A, Lee SY, Zimmermann H, El Tayeb A, Yegutkin GG, Sträter N, Müller CE. X-ray co-crystal structure guedes the way to subnanomolar competitive ecto-5‘-nucleotidase (CD73) inhibitors for cancer immunotherapy. Adv. Therap. 2019, 190075, 1-8.
Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D. Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers. Mar. Drugs, 17(7), 390
May 2019
Marx D, Schnakenburg G, Grimme S, Christa E. Müller CE. Structural and conformational studies on carboxamides of 5,6-diaminouracils –percursors of biologically active xanthine derivatives. Molecules 2019, 24, 1-16.
Lui R, Li X, Wei J, Lui S, Chnag Y, Zhang J, Zhang J, Zhang X, Fuhr U, Taubert M, Tian X. A Single Dos of Baicalin Has No clinically significant Effect on the Pharmacokinetics of Cyclosporin A in Healthy Chinese Volunteers. Front Pharmacol 10, 518
Lindner S, Steinebach C, Kehm H, Mangold M, Gütschow M, Kröhnke J. Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTASCs. J. Vis. Exp. 2019, 147 e59472
Lui R, Li X, Wei Y et al.A single dose of Baicalin has no clinically significant effect on the pharmacokinetics of cyclosporin A in healthy Chinese volunteers. Front Pharmacol. 2019 May 14; 10:518
Steinebach C, Sosic I, Lindner S, Bricelj A, Kohl F, Ng YLD, Monschke M, Wagner KG, Krönke J, Gütschow M. A MedChem toolbox for cereblon-directed PROTACs. Med. Chem. Commun. 2019, 10, 1037-1041
April 2019
D,,,,,,,,,,, H,, GM,,, . Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. J. Biol. Chem. 2019, 294, 5757-5758
Nassir M, Mirza S, Arad U, Lee Sy, Rafehi M, Attah JY, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B. Identification of adenine-N9-(methoxy)-ethyl-ß-bisphosphonateas NPP1 inhibitor attenuates NPPase activity in humanosteoarthritic chondrocytes. Purinergic Signalling, 15:247-263
Bäuml CA, Schmitz T, Paul Georg AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle AL, Wolberg AS, Pötzsch B, Oldenburg J, Biswas A, Imhof D. Coagualation Factor XIIIa Inhibitor Trigegin: On the Role of Disulfide Bonds for Folding, Stability, and Function. J. Med. Chem. April 2019; 62: 3513-3523
March 2019
Jiang J, Seel CJ, Temirak A, Namasivayam V, Arridu A, Schabikowski J, Baqi Y, Hinz S, Hockemeyer J, Müller C E. A2B Adenosine receptor antagonists with picomolar potency. J. Med. Chem. 2019, 62, 4032-4055.
Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin G, Müller CE, Kenneth Jacobson K. Structure-activity relationship of purine and pyrimidine nucleotides as ecto-5'-nucleotidase (CD73) inhibitors. J. Med. Chem. 2019, 62, 3677-3695
Li X, Zoller M, Fuhr U et al. Ciprofloxacin in critically ill subjects: Considering hepatic function, age and sex to choose the optimal dose. J Antimicrob Chemother 2019; 74: 682-690
Bueschbell B, Barreto CAV, Prteo AJ, Schiedel AC, Moreira IS. A complete Assessmenet of Dopamine Receptor-Ligand Interactions throught Computational Methods. Molecules 2019, 24, 1196
Bäuml CA, Schmitz T, Paul George AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle L A, Wolberg, SA, Pötzsch B, Oldenburg J, Biswas A, Imhof D. Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function. J. Med. Chem., 62(7), 3513−3523
February 2019
Marx D, Wingen LM, Schnakenburg G, Müller CE, Scholz MS: Fast, efficient, and versatile synthesis of 6-amino-5-carboxamidouracils as precursors for 8-substituted xanthines. Front. Chem. 2019, 7, 1-15; doi: 10.3389/fchem.2019.00056.
Junkert A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Ducca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yeguthin GG, Müller CE, Jacobsn KA. Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) inhibitors. J. Med. Chem. 2019; 62; 3677-3695
Kumar A, Wißbrock A, Bellstedt P, Lang A, Ramachandran R, Wiedemann C, Imhof D, Ohlenschläger O. 1H, 13C, and 15N resonance assignments of the cytokine interleukin-36β isoform-2. Biomol. NMR. Assign., 13(1), 155-161
January 2019
Steinebach C, Kehm H, Lindner S, Vu LP, Köpff S, Lózep Mármol A, Weiler C, Wagner KG, Krönke J, Gütschow M. PROTAC-mediated crosstalk between E3 ligases. Chem. Commun. 2019, 55, 1821-1824
Fuhr U, Hsin C, Li X et al. Assessment of pharmacokinetic drug-drug interaction in Humans: In Vivo probe substrates for drug metabolism and drug transport revisited. Annu Rev Pharmacol Toxicol 2019; 59: 507-36
Wißbrock A, Paul George AA, Brewitz HH, Kühl,T, Imhof D. The Molecular Basis of Transient Heme-Protein Interactions: Analysis, Concept and Implementation. Biosci. Rep., 39(1), BSR20181940
2018
December 2018
Jakubzig B, Baltes F, Henze S, Schlesinger M, Bendas G. Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells - Deciphering Novel Potential Targets for a Cell Sensitization. Cancers (Basel) 10 (2018)
Gitlin-Domagalska A, Mangold M, Dębowski D, Łęgowska A, Gütschow M, Rolka K.
Matriptase-2: Monitoring and Inhibiting its Proteolytic Activity. Future Med. Chem. 2018, 10, 2745-2761.
November 2018
Reyes-Resina I, Navarro G, Aguinaga D, Canela EI, Schoeder CT, Zaluski M, Kiec-Kononowicz K, Saura CA, Müller CE, Franco F. Molecular and functional interaction between GPR18 and cannabinoid CB2 G protein-coupled receptors. Relevance in neurodegenerative diseases. Biochem. Pharmacol. 2018, 157, 169-179
Moghadaam AJ, Crüsemann M, Alanjary M, Harms H, Dávila-Céspedes A, Blom J, Poehlein A, Ziemert N, König GM, Schäberle TF. Analysis of the genome and metabolme of marine Myxobacteria reveals high potential for biosynthesis of novel specialized metabolites. Scientific reports 2018 Nov. 9; 8 (16600)
Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E. Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels. ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254.
October 2018
Hoß SG, Grundmann M, Benkel T, Gockel LM, Schwarz S, Kostenis E, Schlesinger M, Ilan N, Vlodavsky I, Bendas G. Pro-Angiogenic Effects of Latent Heparanase and Thrombin Receptor-Mediated Pathways-Do They Share a Common Ground in Melanoma Cells? Thromb Haemost 118 (2018) 1803–14
Ponert JM, Gockel LM, Henze S, Schlesinger M. Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells. Mol Basel Switz 23 (2018)
Gockel LM, Ponert JM, Schwarz S, Schlesinger M, Bendas G. The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways. Mol Basel Switz 23 (2018)
Heimer P, Schmitz T, Bäuml CA, Imhof D. Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities. J. Vis. Exp. 2018 Oct. 2; (140) e58368
Steinebach C, Ambrozak A, Dosa S, Beedie SL, Strope JD; Schnakenburg G, Figg WD, Gütschow M. Synthesis, Strucutural Characterization and Antiangiogenic Activity of Polyfluorinated Benzamides. ChemMedChem 2018 Oct 8; 13(19):2080-2089
Moghaddam AJ, Dávila-Céspedes A, Kehraus S, Crüsemann M, Köse M, Müller CE, König GM. Cyclopropane-containing fatty acids from the marine bacterium Labrenzia sp. 011 with antimicrobial and GPR84 actvity. Mar. drugs 2018 Oct 8; 16 (10)
September 2018
Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, Köpff S, Carr SA, Gütschow M, Krönke J. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem. Biol. 2018 Sep 21;13(9): 2771-2782
July 2018
Schoeder CT, Kaleta M, Mahardhika A, Olejarz-Maciej A, Łaźewska D, Kieć-Kononowicz K, Müller CE. Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18. Eur. J. Med. Chem. 2018, 155, 381-397.
June 2018
Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai HF, Müller CE, Kostenis E, König GM, Crüsemann M. Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359. J. Nat. Prod. 2018, 81, 1628-1635.
Breuer C, Lemke C, Schmitz J, Bartz U, Gütschow M. Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins. Bioorg Med Chem 2018 June 15; 28 (11) 2008-2012
Reher R, Kühl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D. Deciphering specificity determinants for FR900359-derived Gαq inhibitors based on computational and structure-activity studies. ChemMedChem 2018 June 16; 13(16) 1634-1643
Kotz S, Kullmann M, Kalayda GV, Dyballa-Rukes N, Jaehde U, Metzger S. Optimized two-dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA-cisplatin-protein adducts in ovarian cancer cells. Electrophoresis 2018 June; 39(12): 1488-1496
May 2018
Schiedel AC, Kose M, Barreto C, Bueschbell B, Morra G, Sensoy O, Moreira IS. Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers. Curr Top Med Chem May 2018; 18 (8) 714-746
April 2018
Mangold M, Gütschow M, Stirnberg M. A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2. Pharmaceuticals 2018, 11, 49.
Schoeder CT, Hess C, Madea B, Meiler J, Müller CE. Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds. Forensic Toxicol. 2018, 36, 385-403.
Köse M, Gollos S, Karcz T, Fiene A, Heisig F, Behrenswerth A, Kieć-Kononowicz K, Namasivayam V, Müller CE. Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry. J. Med. Chem. 2018, 61, 4301-4316
Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X et al. Drinking ethanol has few acute effects on CYp2C9, CYP2C19, NAT2, and P-Glycoprotein activities but somewhat inhibits CYP1A2, CYP2D5, and intestinal CYP3A: So What? Clin Pharmacol Ther 2018; 104:1249-59
Moghaddam AJ, Poehlein A, Fisch K, Alanjary M, Daniel R, König GM, Schäberle TF. Draft genome sequences of the obligatory marine myxobacterial strains Enhygromyxa salina SWB005 ans SWB007. Genome announc. 2018 April 26; 6(17) e00324-18
Kotz S, Kullmann M, Kalayda GV, Dyballa-Rukes N, Jaehde U, Metzger S.
Optimized two-dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA-cisplatin-protein adducts in ovarian cancer cells.
Electrophoresis. 2018; 39: 1488-1496.
March 2018
Hinz S, Navarro G, Barrot-Escuela D, Seibt BF, Ammon YC, de Filippo E, Danish A, Lacher SK, Cervinková B, Rafehi M, Fuxe K, Schiedel AC, Franco R, Müller CE. Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors. Oncotarget 2018, 9, 13593-13611
Sarin N, Engel F, Rothweiler F, Cinatl J, Michaelis M, Frötschl R, Fröhlich H, Kalayda GV.
Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach
Int J Mol Sci. 2018; 19: 767.
February 2018
Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D. Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation. Anal.Chem. 2018 Feb. 03; 90(5) 3321-3327
Kumar A, Wißbrock A, Goradia N, Bellstedt P, Ramachandran R, Imhof D. Ohlenschläger O. Heme interaction on the intrinsically disorderd N-terminal peptide segment of human cystathionine-ß-synthase. SciRep. 2018 Feb. 6; 8:2474
January 2018
Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Carbo-Pinto M, ReuterT, Kehraus S, Hallab A, Schäberle FT, Fleischmann BK, Kostenis E, Wenzel D, Müller CE, Kikuchi Y, Piel J, Carlier A, Eberl L, König GM. Heterologous expression, biosynthetic studies and ecological function of the selective Gq-signaling-inhibitor FR900359. Angew. Chem. Int. Ed. 2018, 57, 836-840.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Lack of beta-arrestin signaling in the absence of active G proteins. Nature Commun. 2018, 9, 341.
Ponert JM, Schwarz S, Haschemi R, Müller J, Pötzsch B, Bendas G. Schlesinger, M The mechanisms how heparin affects the tumor cell induced VEGF and chemokine release from platelets to attenuate the early metastatic niche formation. PLoS One. 13(1) (2018)
Kranawetvogl A, Küppers J, Siegert M, Gütschow M, Worek F, Thiermann H, Elsinghorst PW, John H. Bioanalytical Verification of V-type Nerve Agent Exposure: Simultaneous Detection of Phosphonylated Tyrosines and Cysteine-containing Disulfide-adducts Derived from Human Albumin. Anal. Bioanal. Chem. 2018, 410, 1463-1474.
2017
December 2017
Fisch KM, Hertzer C, Böhringer N, Wuisan ZG, Schillo D, Bara R, Kaligis F,Wägele H, König GM, Schäberle TF. The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds. Mar Drugs. 2017 Dec 7;15(12).
Joerger M, Kraff S, Jaehde U, Hilger RA, Courtney JB, Cline DJ, Jog S, Baburina I, Miller MC, Salamone SJ. Validation of a Commercial Assay and Decision Support Tool for Routine Paclitaxel Therapeutic Drug Monitoring (TDM). Ther Drug Monit. 2017 Dec;39(6):617-624.
November 2017
Deshpande T, Li T, Herde MK, Becker A, Vatter H, Schwarz MK, Henneberger C, Steinhäuser C, Bedner P. Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. Glia. 2017 Nov;65(11):1809-1820.
October 2017
Rafehi M, Neumann A, Baqi Y, Malik EM, Wiese M, Namasivayam V, Müller CE. Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor. J Med Chem. 2017 Oct 26;60(20):8425-8440.
Danish A, Lee SY, Müller CE. Quantification of green fluorescent protein-(GFP-) tagged membrane proteins by capillary gel electrophoresis. Analyst. 2017 Oct 7;142(19):3648-3655.
September 2017
Barra L, Barac P, König GM, Crüsemann M, Dickschat JS. Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea. Org Biomol Chem. 2017 Sep 13;15(35):7411-7421.
Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D. Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288.
Piva MBR, Jakubzig B, Bendas G. Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway. Cancers (Basel). 2017 Sep 16;9(9). pii: E125.
Diekstra MH, Fritsch A, Kanefendt F, Swen JJ, Moes D, Sörgel F, Kinzig M, Stelzer C, Schindele D, Gauler T, Hauser S, Houtsma D, Roessler M, Moritz B, Mross K, Bergmann L, Oosterwijk E, Kiemeney LA, Guchelaar HJ, Jaehde U. Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):604-613.
August 2017
Hufendiek P, Stölben SSM, Harms H, Kehraus S, Merten N, Crüsemann M, Arslan I, Gütschow M, Schneider T, König GM. Biosynthetic studies on acetosellin and structure elucidation of a new acetosellin derivative. Planta Med. 2017 Aug;83(12-13):1044-1052.
Kranawetvogl A, Küppers J, Gütschow M, Worek F, Thiermann H, Elsinghorst PW, John H. Identification of novel disulfide adducts between the thiol containing leaving group of the nerve agent VX and cysteine containing tripeptides derived from human serum albumin. Drug Test Anal. 2017 Aug;9(8):1192-1203.
Henrich A, Joerger M, Kraff S, Jaehde U, Huisinga W, Kloft C, Parra-Guillen ZP. Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia. J Pharmacol Exp Ther. 2017 Aug;362(2):347-358.
van der Zanden LFM, Vermeulen SH, Oskarsdottir A, Maurits JSF, Diekstra MHM, Ambert V, Cambon-Thomsen A, Castellano D, Fritsch A, Garcia Donas J, Guarch Troyas R, Guchelaar HJ, Hartmann A, Hulsbergen-van de Kaa C, Jaehde U, Junker K, Martinez-Cardus A, Masson G, Oosterwijk-Wakka J, Radu MT, Rafnar T, Rodriguez-Antona C, Roessler M, Ruijtenbeek R, Stefansson K, Warren A, Wessels L, Eisen T, Kiemeney LALM, Oosterwijk E. Description of the EuroTARGET cohort: A European collaborative project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity. Urol Oncol. 2017 Aug;35(8):529.e9-529.e16.
July 2017
Sarin N, Engel F, Kalayda GV, Mannewitz M, Cinatl J Jr, Rothweiler F, Michaelis M, Saafan H, Ritter CA, Jaehde U, Frötschl R. Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. PLoS One. 2017 Jul;12(7):e0181081.
June 2017
Böhringer N, Fisch KM, Schillo D, Bara R, Hertzer C, Grein F, Eisenbarth JH, Kaligis F, Schneider T, Wägele H, König GM, Schäberle TF. Antimicrobial Potential of Bacteria Associated with Marine Sea Slugs from North Sulawesi, Indonesia. Front Microbiol. 2017 Jun 14;8:1092.
Pfankuchen DB, Baltes F, Batool T, Li JP, Schlesinger M, Bendas G. Heparin antagonizes cisplatin resistance of A2780 ovarian cancer cells by affecting the Wnt signaling pathway. Oncotarget. 2017 Jun 28;8(40):67553-67566.
De Filippo E, Manga P, Schiedel AC. Identification of Novel G Protein-Coupled
Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular
Albinism. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3118-3126.
May 2017
Mueller T, Pfankuchen DB, Wantoch von Rekowski K, Schlesinger M, Reipsch F, Bendas G. The Impact of the Low Molecular Weight Heparin Tinzaparin on the Sensitization of Cisplatin-Resistant Ovarian Cancers-Preclinical In Vivo Evaluation in Xenograft Tumor Models. Molecules. 2017 May 3; 22(5). pii: E728.
Wißbrock A, Imhof D. A tough nut to crack: Intracellular detection and quantification of heme in malaria parasites by a genetically encoded protein sensor. ChemBioChem. 2017 May 26; 18(16) 1561-1564
April 2017
Rafehi M, Malik EM, Neumann A, Abdelrahman A, Hanck T, Namasivayam V, Müller CE, Baqi Y. Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor. J Med Chem. 2017 Apr 13; 60(7):3020-3038.
Häußler D, Schulz-Fincke AC, Beckmann AM, Keils A, Gilberg E, Mangold M, Bajorath J, Stirnberg M, Steinmetzer T, Gütschow M. A Fluorescent-Labeled Phosphono Bisbenzguanidine As an Activity-Based Probe for Matriptase. Chem Eur J. 2017 Apr 19; 23(22):5205-5209.
March 2017
Bogdanov A, Hertzer C, Kehraus S, Nietzer S, Rohde S, Schupp PJ, Wägele H, König GM. Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia). Beilstein J Org Chem. 2017 Mar 13; 13:502-519.
Kanarek AM, Wagner A, Küppers J, Gütschow M, Postina R, Kojro E. Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein. FEBS J. 2017 Mar; 284(5):742-753.
February 2017
Lee SY, Sarkar S, Bhattarai S, Namasivayam V, De Jonghe S, Stephan H, Herdewijn P, El-Tayeb A, Müller CE. Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase 1 (NPP1) Inhibitors. Front Pharmacol. 2017 Feb 15;8:54.
De Filippo E, Schiedel AC, Manga P. Interaction between G Protein-Coupled
Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type
1. J Invest Dermatol. 2017 Feb; 137(2):457-465.
January 2017
Hoß SG, Bendas G. Mass-Sensitive Biosensor Systems to Determine the Membrane Interaction of Analytes. Methods Mol Biol. 2017; 1520:145-157.
2016
December 2016
Hamedani NS, Rühl H, Zimmermann JJ, Heiseler T, Oldenburg J, Mayer G, Pötzsch B, Müller J. In Vitro Evaluation of Aptamer-Based Reversible Inhibition of Anticoagulant Activated Protein C as a Novel Supportive Hemostatic Approach. Nucleic Acid Ther. 2016 Dec; 26(6):355-362.
Ambrozak A, Steinebach C, Gardner ER, Beedie SL, Schnakenburg G, Figg WD, Gütschow M. Synthesis and Antiangiogenic Properties of Tetrafluorophthalimido and Tetrafluorobenzamido Barbituric Acids. ChemMedChem. 2016 Dec 6; 11(23):2621-2629.
November 2016
Brunschweiger A, Koch P, Schlenk M, Rafehi M, Radjainia H, Küppers P, Hinz S, Pineda F, Wiese M, Hockemeyer J, Heer J, Denonne F, Müller CE. 8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. Bioorg Med Chem. 2016 Nov 1; 24(21):5462-5480.
López-Cruz L, Dan-Miguel N, Bayarri P, Baqi Y, Müller CE, Salamone JD, Correa M. Ethanol and caffeine effects on social interaction and recognition in mice; involvement of adenosine A2A and A1 Receptors. Frontiers Behav. Neurosci. 2016 Nov 10; 1-15.
Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger O, Imhof D. Synthesis and evaluation of Abeta-derived and Abeta-independent enhancers of the peroxidase-like activity of heme. J. Med. Chem., 2017, 60 (1), pp 373–385.
October 2016
Burbiel JC, Ghattas W, Küppers P, Köse M, Lacher S, Herzner AM, Kombu RS, Akkinepally RR, Hockemeyer J, Müller CE. 2-Amino[1,2,4]triazolo[1,5-c]quinazolines and derived novel heterocycles: Synthesis and structure-activity relationships of potent adenosine receptor antagonists. ChemMedChem 2016 Oct 11; 2272-2286.
Goradia N, Wißbrock A, Wiedemann C, Bordusa F, Ramachandran R, Imhof D, Ohlenschläger O. 1H, 13C, and 15N resonance assignments for the pro-inflammatory cytokine interleukin-36α. Biomolecular NMR assignments. 2016 Oct 10: 329-333.
Joerger M, von Pawel J, Kraff S, Fischer JR, Eberhardt W, Gauler TC, Mueller L, Reinmuth N, Reck M, Kimmich M, Mayer F, Kopp HG, Behringer DM, Ko YD, Hilger RA, Roessler M, Kloft C, Henrich A, Moritz B, Miller MC, Salamone SJ, Jaehde U. Open-label, randomized study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small-cell lung cancer (NSCLC). Ann Oncol. 2016 Oct; 27:1895-1902
Mir Mohseni M, Höver T, Barra L, Kaiser M, Dorrestein PC, Dickschat JS, Schäberle TF. Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging. Angew Chem Int Ed Engl. 2016 Oct 17; 55(43):13611-13614.
Rafehi M, Burbiel JC, Attah IY, Abdelrahman A, Müller CE. Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925. Purinergic Signal. 2016 Oct 20. [Epub ahead of print]
Braune A, Engst W, Elsinghorst PW, Furtmann N, Bajorath J, Gütschow M, Blaut M. Chalcone Isomerase from Eubacterium ramulus Catalyzes the Ring Contraction of Flavanonols. J Bacteriol. 2016 Oct 7; 198(21):2965-2974.
September 2016
Fiene A, Baqi Y, Malik EM, Newton P, Li W, Lee SY, Hartland EL, Müller CE. Inhibitors for the bacterial Ectonucleotidase Lp1NTPDase from Legionella pneumophila. Bioorg. Med. Chem. 2016 Sep 24; 4363-4371.
Hagelstein V, Ortland I, Wilmer A, Mitchell SA, Jaehde U. Validation of the German patient-reported outcomes of the common terminology criteria for adverse events (PRO-CTCAE). Ann Oncol. 2016 Sep 28; [Epub ahead of print]
Sathanoori R, Bryl-Gorecka P, Müller CE, Erb L, Weisman GA, Olde B, Erlinge D. P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells. Cell Mol Life Sci. 2017 Feb;74(4):731-746.
Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA. Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels. Biochim. Biophys. Acta - General Subjects, 2016 Sep, 1860, 2053-2063.
August 2016
Thiede S, Wosniok P, Herkommer D, Schulz-Fincke AC, Gütschow M, Menche D. Total Synthesis of Leupyrrin B1: a Potent Inhibitor of Human Leukocyte Elastase. Org Lett. 2016 Aug 19; 18(16):3964-7.
Beckmann AM, Gilberg E, Gattner S, Huang TL, Vanden Eynde JJ, Mayence A, Bajorath J, Stirnberg M, Gütschow M. Evaluation of Bisbenzamidines as Inhibitors for Matriptase-2. Bioorg Med Chem Lett. 2016 Aug 1; 26(15):3741-5.
Beckmann AM, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M, Stirnberg M. The intact Kunitz Domain Protects the Amyloid Precursor Protein from Being Processed by Matriptase-2. Biol Chem. 2016 Aug 1; 397(8):777-90.
Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV. The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Nature Scientific Reports 2016 Aug; 6: 31493.
Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder CT, Kieć-Kononowicz K, Brockmeyer NH, Müller CE, Becker C, Altmüller J, Hatt H, Gisselmann G. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Nature Scientific reports 2016 Aug; 6: 32255.
Malik EM, Rashed M, Wingen L, Baqi Y, Müller CE.Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furinishing novel dyes. Dyes and Pigments. 2016 Aug; 131, 33-40.
Park JH, Williams DR, Lee JH, Lee SD, Lee JH, Ko H, Lee GE, Kim S, Lee JM, Abdelrahman A, Müller CE, Jung DW, Kim YC. Potent suppressive effects of 1-piperidinylimidaole based novel P2X7 receptor antagonists on cancer cell migration and invasion. J. Med. Chem. 2016 Aug, 59, 7410-7430.
July 2016
Gupta S, Biswas A, Akhter MS, Krettler C, Reinhart C, Dodt J, Reuter A, Philippou H, Ivaskevicius V, Oldenburg J. Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective. Sci Rep. 2016 Jul 25; 6:30105.
Pezeshkpoor B, Castoldi E, Mahler A, Hanel D, Müller J, Hamedani NS, Biswas A, Oldenburg J, Pavlova A. Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance. J Thromb Haemost. 2016 Jul; 14(7):1353-63.
Lee SY, Perotti A, De Jonghe S, Herdewijn P, Hanck T, Müller CE. Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors. Bioorg. Med. Chem. 2016 Jul, 24, 3157-3165.
Küppers J, Schulz-Fincke AC, Palus J, Giurg M, Skarżewski J, Gütschow M. Convergent Synthesis of two Fluorescent Ebselen-Coumarin Heterodimers. Pharmaceuticals (Basel). 2016 Jul 8;9(3). pii: E43.
Salar S, Lapilover E, Müller J, Hollnagel JO, Lippmann K, Friedman A, Heinemann U. Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin. Neurobiol Dis. 2016 Jul;91:155-65.
June 2016
Häußler D, Mangold M, Furtmann N, Braune A, Blaut M, Bajorath J, Stirnberg M, Gütschow M. Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-based Probes of Matriptase-2. Chemistry. 2016 Jun 13;22(25):8525-35.
Steinebach C, Schulz-Fincke AC, Schnakenburg G, Gütschow M. In Situ Generation and Trapping of Thioimidates: An Intermolecular Tandem Reaction to 4-Acylimino-4H-3,1-benzothiazines. RSC Adv. 2016, 6, 15430-40.
Brewitz HH, Goradia N, Schubert E, Galler K, Kühl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschläger O, Imhof D. Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli. Biochim. Biophys. Acta - General Subjects, 2016 Jun, 1860, 1343-1353.
De Filippo E, Namasivayam V, Zappe L, El-Tayeb A, Schiedel AC, Müller CE. Role of extracellular cysteine residues in the adenosine A2A receptor. Purinergic Signal. 2016 Jun, 12, 313-329.
May 2016
Grizić D, Heimer P, Vranić E, Imhof D, Lamprecht A. From propylene carbonate to 3,5-diacetyl-1,4-dihydro-2,6-lutidine: a novel quantification approach. Talanta, 2016, May, 151, 75-82.
Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE. Pharmacological evaluation of synthesis cannabinoids identified as constituents of spice. Forensic Toxicol. 2016 May; 34, 329-343.
Jacobson KA, Müller CE. Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacol. 2016 May; 104, 31-49.
Mann PA, Müller A, Wolff KA, Fischmann T, Wang H, Reed P, Hou Y, Li W, Müller CE, Xiao J, Murgolo N, Sher X, Mayhood T, Sheth PR, Mirza A, Labroli M, Xiao L, McCoy M, Gill CJ, Pinho MG, Schneider T, Romer T. Chemical genetic analysis and functional characterization of staphylococcal wall teichoic acid 2-epimerases reveals unconventional antibiotic drug targets. PLoS Pathog. 2016 May, 12(5), e1005585.
Wilhelm M, Mueller L, Miller MC, Link K, Holdenrieder S, Bertsch T, Kunzmann V, Stoetzer OJ, Suttmann I, Braess J, Birkmann J, Roessler M, Moritz B, Kraff S, Salamone SJ, Jaehde U. Prospective, Multicenter Study of 5-Fluorouracil Therapeutic Drug Monitoring in Metastatic Colorectal Cancer Treated in Routine Clinical Practice. Clin Colorectal Cancer. 2016 May 7 [Epub ahead of print]
April 2016
Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Nat Commun. 2016 Apr 27;7:11420.
Canton J, Schlam D, Breuer C, Gütschow M, Glogauer M, Grinstein S. Calcium-sensing Receptors Signal Constitutive Macropinocytosis and Facilitate the Uptake of NOD2 Ligands in Macrophages. Nat Commun. 2016 Apr 6;7:11284.
Beckmann AM, Maurer E, Lülsdorff V, Wilms A, Furtmann N, Bajorath J, Gütschow M, Stirnberg M. En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase-2 as a target for Kunitz-type inhibitors. Chembiochem. 2016 Apr 1;17(7):595-604.
March 2016
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016 Mar 9;7:10895.
February 2016
Moghaddam AJ, Boehringer N, Burdziak A, Kunte HJ, Galinski EA; Schäberle TF. Different strategies of osmoadaptation in the closely related marine Myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1. Microbiolgy. 2016 Feb. 03
Mertens MD, Bierwisch A, Li T, Gütschow M, Thiermann H, Wille T, Elsinghorst PW. A Novel Fluorogenic Probe for the Investigation of Free Thiols: Application to Kinetic Measurements of Acetylcholinesterase Activity. Toxicol Lett. 2016 Feb 26;244:161-6.
Häußler D, Gütschow M. Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules. Synthesis 2016, 48 (2), 245-55.
Engelhardt B, Fröhlich H, Kschischo M. Learning (from) the errors of a systems biology model. SciRep. 2016 Feb 11;6:20772.
January 2016
Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Marciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D’Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D. A2A adenosine receptor deletion is protective in a mouse model of tauopathy. Mol. Psychiatry 2016 Jan, 21, 97-107.
Roydeva PG, Beckmann AM, Stirnberg M, Cesar J, Kikelj D, Ilaš J, Gütschow M. 3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach. Pharmaceuticals (Basel). 2016 Jan 13;9(1). pii: E2.
Podurgiel SJ, Spencer T, Kovner R, Baqi Y, Müller CE, Correa M, Salamone JD. Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: reversal with adenosine A2A antagonism. Pharmacol. Biochem. Behav. 2016 Jan, 140, 62-67.
Schmitz J, Li T, Bartz U, Gütschow M. Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry. ACS Med Chem Lett. 2016 7(3):211-6.
Furtmann N, Häußler D, Scheidt T, Stirnberg M, Steinmetzer T, Bajorath J, Gütschow M. Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases. Chemistry. 2016 Jan 11;22(2):610-25.
Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J. The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. J Biol Chem. 2016 Jan 8;291(2):705-18.
Hamedani NS, Müller J. Capillary Electrophoresis for the Selection of DNA Aptamers Recognizing Activated Protein C. Methods Mol Biol. 2016;1380:61-75.
