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BIGS DrugS students and principal investigators have recently successfully published their research results. Congratulations!




 January 2019


Steinebach C, Kehm H, Lindner S, Vu LP, Köpff S, Lózep Mármol A, Weiler C, Wagner KG, Krönke J, Gütschow M. PROTAC-mediated crosstalk between E3 ligases. Chem. Commun. 2019, 55, 1821-1824

Fuhr U, Hsin C, Li X et al. Assessment of pharmacokinetic drug-drug interaction in Humans: In Vivo probe substrates for drug metabolism and drug transport revisited. Annu Rev Pharmacol Toxicol 2019; 59: 507-36

March 2019


Li X, Zoller M, Fuhr U et al. Ciprofloxacin in critically ill subjects: Considering hepatic function, age and sex to choose the optimal dose. J Antimicrob Chemother 2019; 74: 682-690

Bueschbell B, Barreto CAV, Prteo AJ, Schiedel AC, Moreira IS. A complete Assessmenet of Dopamine Receptor-Ligand Interactions throught Computational Methods. Molecules 2019, 24, 1196

April 2019


Bäuml CA, Schmitz T, Paul Georg AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle AL, Wolberg AS, Pötzsch B, Oldenburg J, Biswas A, Imhof D. Coagualation Factor XIIIa Inhibitor Trigegin: On the Role of Disulfide Bonds for Folding, Stability, and Function. J. Med. Chem.  April 2019; 62: 3513-3523

May 2019


Lindner S, Steinebach C, Kehm H, Mangold M, Gütschow M, Kröhnke J. Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTASCs. J. Vis. Exp. 2019, 147 e59472

Lui R, Li X, Wei Y et al. A single dose of Baicalin has no clinically significant effect on the pharmacokinetics of cyclosporin A in healthy Chinese volunteers. Front Pharmacol. 2019 May 14; 10:518

Steinebach C, Sosic  I, Lindner S, Bricelj A, Kohl F, Ng YLD, Monschke M, Wagner KG, Krönke J, Gütschwo M. A MedChem toolbox for cereblon-directed PROTACs. Med. Chem. Commun. 2019, 10, 1037-1041

December 2019

Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martínez-Grau MA, Beadle CD, Vetman T, Dato FM, Bartz U, Elsinghorst PW, Pietsch M, Müller CE, Iriepa I, Wille T, Marco-Contelles J, Gütschow M. Chromenones as Multi-Neurotargeting Inhibitors of Human Enzymes. ACS Omega 2019, 4 22161-22168



 November 2018


Moghadaam AJ, Crüsemann M, Alanjary M, Harms H, Dávila-Céspedes A, Blom J, Poehlein A, Ziemert N, König GM, Schäberle TF. Analysis of the genome and metabolme of marine Myxobacteria reveals high potential for biosynthesis of novel specialized metabolites. Scientific reports 2018 Nov. 9; 8 (16600)

Wu J, Li X, Zhao J et al. Anti-inflammatory and cytotoxic withanolides from Physalis minima. Phytochemistry 2018;155:164-70


October 2018


Heimer P, Schmitz T, Bäuml CA, Imhof D. Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities. J. Vis. Exp. 2018 Oct. 2; (140) e58368


Steinebach C, Ambrozak A, Dosa S, Beedie SL, Strope JD; Schnakenburg G, Figg WD, Gütschow M. Synthesis, Strucutural Characterization and Antiangiogenic Activity of Polyfluorinated Benzamides. ChemMedChem 2018 Oct 8; 13(19):2080-2089


Moghaddam AJ, Dávila-Céspedes A, Kehraus S, Crüsemann M, Köse M, Müller CE, König GM. Cyclopropane-containing fatty acids from the marine bacterium Labrenzia sp. 011 with antimicrobial and GPR84 actvity. Mar. drugs 2018 Oct 8; 16 (10)


September 2018


Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, Köpff S, Carr SA, Gütschow M, Krönke J. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem. Biol. 2018 Sep 21;13(9): 2771-2782


June 2018


Breuer C, Lemke C, Schmitz J, Bartz U, Gütschow M. Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins. Bioorg Med Chem 2018 June 15; 28 (11) 2008-2012

Reher R, Kühl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D. Deciphering specificity determinants for FR900359-derived Gαq inhibitors based on computational and structure-activity studies. ChemMedChem 2018 June 16; 13(16) 1634-1643

Kotz S, Kullmann M, Kalayda GV, Dyballa-Rukes N, Jaehde U, Metzger S. Optimized two-dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA-cisplatin-protein adducts in ovarian cancer cells. Electrophoresis 2018 June; 39(12): 1488-1496


May 2018


Schiedel AC, Kose M, Barreto C, Bueschbell B, Morra G, Sensoy O, Moreira IS. Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers. Curr Top Med Chem May 2018; 18 (8) 714-746


April 2018 


Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X et al. Drinking ethanol has few acute effects on CYp2C9, CYP2C19, NAT2, and P-Glycoprotein activities but somewhat inhibits CYP1A2, CYP2D5, and intestinal CYP3A: So What? Clin Pharmacol Ther 2018; 104:1249-59

Moghaddam AJ, Poehlein A, Fisch K, Alanjary M, Daniel R, König GM, Schäberle TF. Draft genome sequences of the obligatory marine myxobacterial strains Enhygromyxa salina SWB005 ans SWB007. Genome announc. 2018 April 26; 6(17) e00324-18


February 2018


Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D. Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation. Anal.Chem. 2018 Feb. 03; 90(5) 3321-3327


Kumar A, Wißbrock A, Goradia N, Bellstedt P, Ramachandran R, Imhof D. Ohlenschläger O. Heme interaction on the intrinsically disorderd N-terminal peptide segment of human cystathionine-ß-synthase. SciRep. 2018 Feb. 6; 8:2474




December 2017


Fisch KM, Hertzer C, Böhringer N, Wuisan ZG, Schillo D, Bara R, Kaligis F,Wägele H, König GM, Schäberle TF. The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds. Mar Drugs. 2017 Dec 7;15(12).


Joerger M, Kraff S, Jaehde U, Hilger RA, Courtney JB, Cline DJ, Jog S, Baburina I, Miller MC, Salamone SJ. Validation of a Commercial Assay and Decision Support Tool for Routine Paclitaxel Therapeutic Drug Monitoring (TDM). Ther Drug Monit. 2017 Dec;39(6):617-624.


November 2017

Deshpande T, Li T, Herde MK, Becker A, Vatter H, Schwarz MK, Henneberger C, Steinhäuser C, Bedner P. Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. Glia. 2017 Nov;65(11):1809-1820.


October 2017


Rafehi M, Neumann A, Baqi Y, Malik EM, Wiese M, Namasivayam V, Müller CE. Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor. J Med Chem. 2017 Oct 26;60(20):8425-8440.


Danish A, Lee SY, Müller CE. Quantification of green fluorescent protein-(GFP-) tagged membrane proteins by capillary gel electrophoresis. Analyst. 2017 Oct 7;142(19):3648-3655.


September 2017


Barra L, Barac P, König GM, Crüsemann M, Dickschat JS. Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea. Org Biomol Chem. 2017 Sep 13;15(35):7411-7421.


Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D. Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288.


Piva MBR, Jakubzig B, Bendas G. Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway. Cancers (Basel). 2017 Sep 16;9(9). pii: E125.


Diekstra MH, Fritsch A, Kanefendt F, Swen JJ, Moes D, Sörgel F, Kinzig M, Stelzer C, Schindele D, Gauler T, Hauser S, Houtsma D, Roessler M, Moritz B, Mross K, Bergmann L, Oosterwijk E, Kiemeney LA, Guchelaar HJ, Jaehde U. Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):604-613.


August 2017


Hufendiek P, Stölben SSM, Harms H, Kehraus S, Merten N, Crüsemann M, Arslan I, Gütschow M, Schneider T, König GM. Biosynthetic studies on acetosellin and structure elucidation of a new acetosellin derivative. Planta Med. 2017 Aug;83(12-13):1044-1052.


Kranawetvogl A, Küppers J, Gütschow M, Worek F, Thiermann H, Elsinghorst PW, John H. Identification of novel disulfide adducts between the thiol containing leaving group of the nerve agent VX and cysteine containing tripeptides derived from human serum albumin. Drug Test Anal. 2017 Aug;9(8):1192-1203.


Henrich A, Joerger M, Kraff S, Jaehde U, Huisinga W, Kloft C, Parra-Guillen ZP. Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia. J Pharmacol Exp Ther. 2017 Aug;362(2):347-358. 


van der Zanden LFM, Vermeulen SH, Oskarsdottir A, Maurits JSF, Diekstra MHM, Ambert V, Cambon-Thomsen A, Castellano D, Fritsch A, Garcia Donas J, Guarch Troyas R, Guchelaar HJ, Hartmann A, Hulsbergen-van de Kaa C, Jaehde U, Junker K, Martinez-Cardus A, Masson G, Oosterwijk-Wakka J, Radu MT, Rafnar T, Rodriguez-Antona C, Roessler M, Ruijtenbeek R, Stefansson K, Warren A, Wessels L, Eisen T, Kiemeney LALM, Oosterwijk E. Description of the EuroTARGET cohort: A European collaborative project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity. Urol Oncol. 2017 Aug;35(8):529.e9-529.e16.


July 2017


Sarin N, Engel F, Kalayda GV, Mannewitz M, Cinatl J Jr, Rothweiler F, Michaelis M, Saafan H, Ritter CA, Jaehde U, Frötschl R. Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. PLoS One. 2017 Jul;12(7):e0181081.


June 2017


Böhringer N, Fisch KM, Schillo D, Bara R, Hertzer C, Grein F, Eisenbarth JH, Kaligis F, Schneider T, Wägele H, König GM, Schäberle TF. Antimicrobial Potential of Bacteria Associated with Marine Sea Slugs from North Sulawesi, Indonesia. Front Microbiol. 2017 Jun 14;8:1092.


Pfankuchen DB, Baltes F, Batool T, Li JP, Schlesinger M, Bendas G. Heparin antagonizes cisplatin resistance of A2780 ovarian cancer cells by affecting the Wnt signaling pathway. Oncotarget. 2017 Jun 28;8(40):67553-67566.


De Filippo E, Manga P, Schiedel AC. Identification of Novel G Protein-Coupled
Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular
Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3118-3126. 


May 2017


Mueller T, Pfankuchen DB, Wantoch von Rekowski K, Schlesinger M, Reipsch F, Bendas G. The Impact of the Low Molecular Weight Heparin Tinzaparin on the Sensitization of Cisplatin-Resistant Ovarian Cancers-Preclinical In Vivo Evaluation in Xenograft Tumor Models. Molecules. 2017 May 3; 22(5). pii: E728.


Wißbrock A, Imhof D. A tough nut to crack: Intracellular detection and quantification of heme in malaria parasites by a genetically encoded protein sensor. ChemBioChem. 2017 May 26; 18(16) 1561-1564


April 2017


Rafehi M, Malik EM, Neumann A, Abdelrahman A, Hanck T, Namasivayam V, Müller CE, Baqi Y. Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor. J Med Chem. 2017 Apr 13; 60(7):3020-3038.


Häußler D, Schulz-Fincke AC, Beckmann AM, Keils A, Gilberg E, Mangold M, Bajorath J, Stirnberg M, Steinmetzer T, Gütschow M. A Fluorescent-Labeled Phosphono Bisbenzguanidine As an Activity-Based Probe for Matriptase. Chem Eur J. 2017 Apr 19; 23(22):5205-5209.


March 2017


Bogdanov A, Hertzer C, Kehraus S, Nietzer S, Rohde S, Schupp PJ, Wägele H, König GM. Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia). Beilstein J Org Chem. 2017 Mar 13; 13:502-519.


Kanarek AM, Wagner A, Küppers J, Gütschow M, Postina R, Kojro E. Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein. FEBS J. 2017 Mar; 284(5):742-753.


February 2017


Lee SY, Sarkar S, Bhattarai S, Namasivayam V, De Jonghe S, Stephan H, Herdewijn P, El-Tayeb A, Müller CE. Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase 1 (NPP1) Inhibitors. Front Pharmacol. 2017 Feb 15;8:54.


De Filippo E, Schiedel AC, Manga P. Interaction between G Protein-Coupled
Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type
J Invest Dermatol. 2017 Feb; 137(2):457-465.


January 2017


Hoß SG, Bendas G. Mass-Sensitive Biosensor Systems to Determine the Membrane Interaction of Analytes. Methods Mol Biol. 2017; 1520:145-157.



December 2016

Hamedani NS, Rühl H, Zimmermann JJ, Heiseler T, Oldenburg J, Mayer G, Pötzsch B, Müller J. In Vitro Evaluation of Aptamer-Based Reversible Inhibition of Anticoagulant Activated Protein C as a Novel Supportive Hemostatic Approach. Nucleic Acid Ther. 2016 Dec; 26(6):355-362.


Ambrozak A, Steinebach C, Gardner ER, Beedie SL, Schnakenburg G, Figg WD, Gütschow M. Synthesis and Antiangiogenic Properties of Tetrafluorophthalimido and Tetrafluorobenzamido Barbituric Acids. ChemMedChem. 2016 Dec 6; 11(23):2621-2629.


November 2016


Brunschweiger A, Koch P, Schlenk M, Rafehi M, Radjainia H, Küppers P, Hinz S, Pineda F, Wiese M, Hockemeyer J, Heer J, Denonne F, Müller CE. 8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. Bioorg Med Chem. 2016 Nov 1; 24(21):5462-5480.


López-Cruz L, Dan-Miguel N, Bayarri P, Baqi Y, Müller CE, Salamone JD, Correa M. Ethanol and caffeine effects on social interaction and recognition in mice; involvement of adenosine A2A and A1 Receptors. Frontiers Behav. Neurosci. 2016 Nov 10; 1-15.


Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger O, Imhof D. Synthesis and evaluation of Abeta-derived and Abeta-independent enhancers of the peroxidase-like activity of heme. J. Med. Chem., 2017, 60 (1), pp 373–385.


October 2016

Burbiel JC, Ghattas W, Küppers P, Köse M, Lacher S, Herzner AM, Kombu RS, Akkinepally RR, Hockemeyer J, Müller CE. 2-Amino[1,2,4]triazolo[1,5-c]quinazolines and derived novel heterocycles: Synthesis and structure-activity relationships of potent adenosine receptor antagonists. ChemMedChem 2016 Oct 11; 2272-2286.


Goradia N, Wißbrock A, Wiedemann C, Bordusa F, Ramachandran R, Imhof D, Ohlenschläger O. 1H, 13C, and 15N resonance assignments for the pro-inflammatory cytokine interleukin-36α. Biomolecular NMR assignments. 2016 Oct 10: 329-333.

Joerger M, von Pawel J, Kraff S, Fischer JR, Eberhardt W, Gauler TC, Mueller L, Reinmuth N, Reck M, Kimmich M, Mayer F, Kopp HG, Behringer DM, Ko YD, Hilger RA, Roessler M, Kloft C, Henrich A, Moritz B, Miller MC, Salamone SJ, Jaehde U.  Open-label, randomized study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small-cell lung cancer (NSCLC). Ann Oncol. 2016 Oct; 27:1895-1902

Mir Mohseni M, Höver T, Barra L, Kaiser M, Dorrestein PC, Dickschat JS, Schäberle TF. Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging. Angew Chem Int Ed Engl. 2016 Oct 17; 55(43):13611-13614.

Rafehi M, Burbiel JC, Attah IY, Abdelrahman A, Müller CE. Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925. Purinergic Signal. 2016 Oct 20. [Epub ahead of print]


Braune A, Engst W, Elsinghorst PW, Furtmann N, Bajorath J, Gütschow M, Blaut M. Chalcone Isomerase from Eubacterium ramulus Catalyzes the Ring Contraction of Flavanonols. J Bacteriol. 2016 Oct 7; 198(21):2965-2974.


September 2016


Fiene A, Baqi Y, Malik EM, Newton P, Li W, Lee SY, Hartland EL, Müller CE. Inhibitors for the bacterial Ectonucleotidase Lp1NTPDase from Legionella pneumophila. Bioorg. Med. Chem. 2016 Sep 24; 4363-4371.


Hagelstein V, Ortland I, Wilmer A, Mitchell SA, Jaehde U. Validation of the German patient-reported outcomes of the common terminology criteria for adverse events (PRO-CTCAE). Ann Oncol. 2016 Sep 28; [Epub ahead of print]


Sathanoori R, Bryl-Gorecka P, Müller CE, Erb L, Weisman GA, Olde B, Erlinge D. P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells. Cell Mol Life Sci. 2017 Feb;74(4):731-746.


Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA. Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels. Biochim. Biophys. Acta - General Subjects, 2016 Sep, 1860, 2053-2063.


August 2016


Thiede S, Wosniok P, Herkommer D, Schulz-Fincke AC, Gütschow M, Menche D. Total Synthesis of Leupyrrin B1: a Potent Inhibitor of Human Leukocyte Elastase. Org Lett. 2016 Aug 19; 18(16):3964-7.


Beckmann AM, Gilberg E, Gattner S, Huang TL, Vanden Eynde JJ, Mayence A, Bajorath J, Stirnberg M, Gütschow M. Evaluation of Bisbenzamidines as Inhibitors for Matriptase-2. Bioorg Med Chem Lett. 2016 Aug 1; 26(15):3741-5.


Beckmann AM, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M, Stirnberg M. The intact Kunitz Domain Protects the Amyloid Precursor Protein from Being Processed by Matriptase-2. Biol Chem. 2016 Aug 1; 397(8):777-90.


Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV. The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Nature Scientific Reports 2016 Aug; 6: 31493.


Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder CT, Kieć-Kononowicz K, Brockmeyer NH, Müller CE, Becker C, Altmüller J, Hatt H, Gisselmann G. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Nature Scientific reports 2016 Aug; 6: 32255.


Malik EM, Rashed M, Wingen L, Baqi Y, Müller CE.Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furinishing novel dyes. Dyes and Pigments. 2016 Aug; 131, 33-40.


Park JH, Williams DR, Lee JH, Lee SD, Lee JH, Ko H, Lee GE, Kim S, Lee JM, Abdelrahman A, Müller CE, Jung DW, Kim YC. Potent suppressive effects of 1-piperidinylimidaole based novel P2X7 receptor antagonists on cancer cell migration and invasion. J. Med. Chem. 2016 Aug, 59, 7410-7430.


July 2016

Gupta S, Biswas A, Akhter MS, Krettler C, Reinhart C, Dodt J, Reuter A, Philippou H, Ivaskevicius V, Oldenburg J. Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective. Sci Rep. 2016 Jul 25; 6:30105.


Pezeshkpoor B, Castoldi E, Mahler A, Hanel D, Müller J, Hamedani NS, Biswas A, Oldenburg J, Pavlova A. Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance. J Thromb Haemost. 2016 Jul; 14(7):1353-63.


Lee SY, Perotti A, De Jonghe S, Herdewijn P, Hanck T, Müller CE. Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors. Bioorg. Med. Chem. 2016 Jul, 24, 3157-3165.


Küppers J, Schulz-Fincke AC, Palus J, Giurg M, Skarżewski J, Gütschow M. Convergent Synthesis of two Fluorescent Ebselen-Coumarin Heterodimers. Pharmaceuticals (Basel). 2016 Jul 8;9(3). pii: E43.


Salar S, Lapilover E, Müller J, Hollnagel JO, Lippmann K, Friedman A, Heinemann U. Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin. Neurobiol Dis. 2016 Jul;91:155-65.


June 2016

Häußler D, Mangold M, Furtmann N, Braune A, Blaut M, Bajorath J, Stirnberg M, Gütschow M. Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-based Probes of Matriptase-2. Chemistry. 2016 Jun 13;22(25):8525-35.


Steinebach C, Schulz-Fincke AC, Schnakenburg G, Gütschow M. In Situ Generation and Trapping of Thioimidates: An Intermolecular Tandem Reaction to 4-Acylimino-4H-3,1-benzothiazines. RSC Adv. 2016, 6, 15430-40.


Brewitz HH, Goradia N, Schubert E, Galler K, Kühl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschläger O, Imhof D. Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli. Biochim. Biophys. Acta - General Subjects, 2016 Jun, 1860, 1343-1353.


De Filippo E, Namasivayam V, Zappe L, El-Tayeb A, Schiedel AC, Müller CE. Role of extracellular cysteine residues in the adenosine A2A receptor. Purinergic Signal. 2016 Jun, 12, 313-329.


May 2016


Grizić D, Heimer P, Vranić E, Imhof D, Lamprecht A. From propylene carbonate to 3,5-diacetyl-1,4-dihydro-2,6-lutidine: a novel quantification approach. Talanta, 2016, May, 151, 75-82.


Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE. Pharmacological evaluation of synthesis cannabinoids identified as constituents of spice. Forensic Toxicol. 2016 May; 34, 329-343.


Jacobson KA, Müller CE. Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacol. 2016 May; 104, 31-49.


Mann PA, Müller A, Wolff KA, Fischmann T, Wang H, Reed P, Hou Y, Li W, Müller CE, Xiao J, Murgolo N, Sher X, Mayhood T, Sheth PR, Mirza A, Labroli M, Xiao L, McCoy M, Gill CJ, Pinho MG, Schneider T, Romer T. Chemical genetic analysis and functional characterization of staphylococcal wall teichoic acid 2-epimerases reveals unconventional antibiotic drug targets. PLoS Pathog. 2016 May, 12(5), e1005585.


Wilhelm M, Mueller L, Miller MC, Link K, Holdenrieder S, Bertsch T, Kunzmann V, Stoetzer OJ, Suttmann I, Braess J, Birkmann J, Roessler M, Moritz B, Kraff S, Salamone SJ, Jaehde U. Prospective, Multicenter Study of 5-Fluorouracil Therapeutic Drug Monitoring in Metastatic Colorectal Cancer Treated in Routine Clinical Practice. Clin Colorectal Cancer. 2016 May 7 [Epub ahead of print]


April 2016


Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Nat Commun. 2016 Apr 27;7:11420.


Canton J, Schlam D, Breuer C, Gütschow M, Glogauer M, Grinstein S. Calcium-sensing Receptors Signal Constitutive Macropinocytosis and Facilitate the Uptake of NOD2 Ligands in Macrophages. Nat Commun. 2016 Apr 6;7:11284.


Beckmann AM, Maurer E, Lülsdorff V, Wilms A, Furtmann N, Bajorath J, Gütschow M, Stirnberg M. En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase-2 as a target for Kunitz-type inhibitors. Chembiochem. 2016 Apr 1;17(7):595-604.


March 2016

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016 Mar 9;7:10895.


February 2016

Moghaddam AJ, Boehringer N, Burdziak A, Kunte HJ, Galinski EA; Schäberle TF. Different strategies of osmoadaptation in the closely related marine Myxobacteria Enhygromyxa salina SWB007 and Plesiocystis pacifica SIR-1. Microbiolgy. 2016 Feb. 03


Mertens MD, Bierwisch A, Li T, Gütschow M, Thiermann H, Wille T, Elsinghorst PW. A Novel Fluorogenic Probe for the Investigation of Free Thiols: Application to Kinetic Measurements of Acetylcholinesterase Activity. Toxicol Lett. 2016 Feb 26;244:161-6.


Häußler D, Gütschow M. Fluorescently Labeled Amino Acids as Building Blocks for Bioactive Molecules. Synthesis 2016, 48 (2), 245-55.


Engelhardt B, Fröhlich H, Kschischo M. Learning (from) the errors of a systems biology model. SciRep. 2016 Feb 11;6:20772.


January 2016


Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Marciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D’Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D. A2A adenosine receptor deletion is protective in a mouse model of tauopathy. Mol. Psychiatry 2016 Jan, 21, 97-107.


Roydeva PG, Beckmann AM, Stirnberg M, Cesar J, Kikelj D, Ilaš J, Gütschow M. 3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach. Pharmaceuticals (Basel). 2016 Jan 13;9(1). pii: E2.


Podurgiel SJ, Spencer T, Kovner R, Baqi Y, Müller CE, Correa M, Salamone JD. Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: reversal with adenosine A2A antagonism. Pharmacol. Biochem. Behav. 2016 Jan, 140, 62-67.


Schmitz J, Li T, Bartz U, Gütschow M. Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry. ACS Med Chem Lett. 2016 7(3):211-6.


Furtmann N, Häußler D, Scheidt T, Stirnberg M, Steinmetzer T, Bajorath J, Gütschow M. Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases. Chemistry. 2016 Jan 11;22(2):610-25.


Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J. The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. J Biol Chem. 2016 Jan 8;291(2):705-18.


Hamedani NS, Müller J. Capillary Electrophoresis for the Selection of DNA Aptamers Recognizing Activated Protein C. Methods Mol Biol. 2016;1380:61-75.

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