Alexander Pfeifer
Prof. Dr. med. Alexander Pfeifer
Faculty of Medicine. Board member, speaker
  • Institute for Pharmacology and Toxicology
Research topics
  • metabolism of adipose tissue
  • viral vectors & nanomedicine
  • GPCR & purine signaling
  • NO/cGMP signaling
Our main research focus lies on signaling pathways and how they can be manipulated with pharmacological tools and drugs to treat diseases. We investigate mainly the cGMP pathway and G protein coupled receptors in metabolically relevant tissues (adipose tissue and muscle), vessels and in immune cells. We also develop therapeutic approaches using nanoparticles and viral vectors, A major focus of our work is energy homeostasis and obesity. Obesity is a global health problem and is linked with cardiovascular disease, hypertension, diabetes and cancer. Obesity is caused by an imbalance of energy consumption and dissipation. We are especially interested in mechanisms of energy expenditure and how they can be used to treat metabolic diseases. , We apply state-of-the-art technologies including genetic tools like lentiviral vectors and transgenic mouse models and in vivo measurements especially of metabolism e.g using metabolic cages.
Selected publications

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature (2022).

EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.  Commun Biol. 2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle. Commun Biol. 2022 Mar 3;5(1):197. doi: 10.1038/s42003-022-03140-2. PMID: 35241778

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037. Epub 2021

Quantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy. ACS Nano. 2021 Jan 26;15(1):434-446. doi: 10.1021/acsnano.0c03229. Epub 2020 Dec

FOXK1 and FOXK2 regulate aerobic glycolysis Nature. 2019 Feb;566(7743):279-283. doi: 10.1038/s41586-019-0900-5. Epub 2019 Jan

More publications - PubMed

Alexander Pfeifer
Prof. Dr. med. Alexander Pfeifer
Faculty of Medicine. Board member, speaker

Venusberg-Campus 1

53127 Bonn

Wird geladen