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Research Interests

 

  • Medical Chemistry, Chemical Biology and Molecular Pharmacology of Purinergic Receptors (adenosine, P2Y, P2X, adenine receptors)
  • G protein-coupled receptors / orphan GPCRs
  • Ectonucleotidase inhibitors
  • Development of screening assays

 

Technologies / Resources

 

  • Synthesis of drug molecules (small molecules)
  • Combinatorial synthesis, microwave-assisted synthesis
  • Molecular biological techniques (expression in mammalian cells, insect cells and yeast), mutagenesis studies
  • Development of radioligands (including PET-ligands), fluorescent ligands and ESR probes
  • Isotope Laboratories
  • High-throughput screening facilities
  • Proprietary compound library
  • GM-S2-laboratories
  • NMR (500 MHz, 600 MHz), LCMS, CE

 

Joint Projects

 

  • BioPharma-Neuroallianz (Steering Committee Member, principal investigator (PI) of several projects)
  • DFG-Forschergruppe FOR2372 (PI of one project on Gq-proteins)
  • Bonn International Graduate Research School of Drug Sciences (BIGS-DrugS), Project leader
  • DFG-Graduiertenkolleg GRK1873 (PI of one project, Co-PI of one project)
  • Collaboration with biotech/pharma companies
  • DAAD Project International Master of Science in Drug Research with COMSATS University, Abbotabad, Pakistan
  • Alzheimer Forschung Initiative: A2A Receptor Modulation for the Therapy of Alzheimer's Disease
  • Collaboration with Dr. David Blum, Lille, France
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