Dirk Menche
Prof. Dr. rer. nat. Dirk Menche
Affiliations
  • Kekulé-Institute for Organic Chemistry & Biochemistry
Research topics
  • Natural Products Chemistry:
  • Total Synthesis
  • Synthetic Methodology
  • NMR-Studies
  • Biomolecular Evaluation
The exquisite and varied architectures of natural products provide a rich pallet for discovery, whether these are used to probe biological mechanisms or to provide the basis for pharmaceutical drug discovery, natural metabolites continue to command attention. For many of these reasons, we are drawn to these structures as testing grounds for synthetic strategies and the development of new methods.
Selected publications

T. Treiber, W.-S. Li, M. Bingel, A. Müller, M. Eckhardt, D. Menche: Total Synthesis of Epicoccolides A and B by Oxidative Skeleton Rearrangement Leads to a Structural Revision and Questions Proposed Biosynthesis. Org. Lett. 2025, 27, 6539−6544.

J. W. Meringdal, D. Menche. Suzuki Miyaura (Hetero )Aryl Cross-Coupling: Recent Findings and Recommendations. Chem. Soc. Rev. 2025, 54, 5746–5765.

A. Babczyk, D. Menche.Total Synthesis of Pentamycin by a Conformationally Biased Double Stille Ring Closure with a Trienyl-bis-stannane. J. Am. Chem. Soc. 2023, 145, 10974-10979. 

S. Scheeff, S. Rivière, J. Ruiz, A. Abdelrahman, A.-C. Schulz-Fincke, M. Köse, F. Tiburcy, H. Wieczorek, M. Gütschow, C. E. Müller, D. Menche. Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. J. Med. Chem. 2020, 63, 1684-1698.

 A.-C. Gnirck, M.-S. Philipp, A. Waterhölter, M. Wunderlich, N. Shaikh, V. Adamiak, L. Henneken, T. Kautz, T. Xiong, D. Klaus, P. Tomczyk, M. M. Al-Bahra, D. Menche, M. Walkenhorst, O. Lantz, A. Willing, M. A. Friese, T. B. Huber, C. F. Krebs, U. Panzer, C. Kurts, J.-E. Turner. Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease. Nature Communications 2023, 14, 7372. 

Dirk Menche
Prof. Dr. rer. nat. Dirk Menche

4.092

Gerhard-Domagk-Str. 1

53121 Bonn

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